Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/31267
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dc.contributor.authorCamara, Edmundo José Nassri
dc.contributor.authorMendonca, Vitor Rosa Ramos
dc.contributor.authorSouza, Ligia C. L.
dc.contributor.authorCarvalho, Juliana S.
dc.contributor.authorLessa, Rudá Alves
dc.contributor.authorGatto, Ramon
dc.contributor.authorBarreto, Luan Oliveira
dc.contributor.authorChiacchio, Giulianna
dc.contributor.authorAmarante, Eduardo
dc.contributor.authorCunha, Monaliza
dc.contributor.authorSilva, Luis S. Alves
dc.contributor.authorGuimarães, Benelson A. C.
dc.contributor.authorBarral Netto, Manoel
dc.date.accessioned2019-01-23T17:54:22Z
dc.date.available2019-01-23T17:54:22Z
dc.date.issued2019
dc.identifier.citationCAMARA, E. J. N. et al. Elevated IL-17 levels and echocardiographic signs of preserved myocardial function in benznidazole-treated individuals with chronic Chagas' disease. International Journal of Infectious Diseases, v. 79, p. 123-130, 2019.
dc.identifier.issn1201-9712
dc.identifier.urihttps://www.arca.fiocruz.br/handle/icict/31267
dc.description.sponsorshipConselho Nacional de Pesquisa e Tecnologia (CNPq), Brazil. VRRM and LCLS were supported by CNPq.
dc.language.isoeng
dc.publisherElsevier
dc.rightsopen access
dc.subject.otherDoença de Chagas
dc.subject.otherTratamento com benznidazol
dc.subject.otherResposta imune
dc.subject.otherCitocinas
dc.subject.otherEcocardiográfico
dc.subject.otherDoppler tecidual
dc.titleElevated IL-17 levels and echocardiographic signs of preserved myocardial function in benznidazole-treated individuals with chronic Chagas' disease
dc.typeArticle
dc.identifier.doi10.1016/j.ijid.2018.11.369
dc.description.abstractenThe immunological and clinical impact of trypanocidal treatment in chronic Chagas' disease (CCD) is unclear. Methodology and findings: Several cytokines were measured in plasma of 66 patients with CCD. Thirtythree patients had been previously treated with benznidazole and 33 had never been treated. The treated group exhibited higher levels of IL-17 (median 142.45 1.22 pg/ml, P = 0.025), which was the only one significantly associated with Bz treatment, especially after adjusting for time of disease and NYHA class (P = 0.024; OR 1.006, 95% CI 1.001-1.010). Compared to untreated patients, the treated group exhibited higher median values of mitral annular E’ lateral (13.0 10.0 cm/s, P = 0.038), S’ infero-lateral (8.9 7.6 cm/s, P = 0.013), S’ septal (8.5 7.4 cm/s, P = 0.034), mean S’ (9.0 7.9 cm/s, P = 0.013) and tricuspid annular S’ (13.3 11.1 cm/s, P = 0.001) and lower values of E/E’ septal (7.2 9.5 cm/s, P = 0.049). After adjustment for time of disease and NYHA class, S’ infero-lateral (P = 0.031), mean S’ (P = 0.049) and S’ tricuspid (P = 0.024) persisted as significantly associated with treatment. Conclusion: The present findings suggest that the group of CCD patients treated with Bz displayed increased plasma levels of IL-17 and preserved myocardial function, reinforcing the idea that Bz treatment may be beneficial.
dc.creator.affilliationUniversidade Federal da Bahia. Faculdade de Medicina. Salvador, BA, Brasil / Universidade Federal da Bahia. Complexo Hospitalar Professor Edgard Santos. Unidade Docente Assistencial de Cardiologia. Salvador, BA, Brasil.
dc.creator.affilliationFundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Medicina. Salvador, BA, Brasil.
dc.creator.affilliationFundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Medicina. Salvador, BA, Brasil.
dc.creator.affilliationFaculdade de Tecnologia e Ciências. Salvador, BA, Brasil.
dc.creator.affilliationUniversidade Federal da Bahia. Faculdade de Medicina. Salvador, BA, Brasil.
dc.creator.affilliationUniversidade Federal da Bahia. Faculdade de Medicina. Salvador, BA, Brasil.
dc.creator.affilliationUniversidade Federal da Bahia. Faculdade de Medicina. Salvador, BA, Brasil.
dc.creator.affilliationUniversidade Federal da Bahia. Faculdade de Medicina. Salvador, BA, Brasil.
dc.creator.affilliationFaculdade de Tecnologia e Ciências. Salvador, BA, Brasil.
dc.creator.affilliationUniversidade Federal da Bahia. Complexo Hospitalar Universitário Professor Edgard Santos. Unidade Docente Assistencial de Cardiologia. Salvador, BA, Brasil.
dc.creator.affilliationUniversidade Federal da Bahia. Complexo Hospitalar Universitário Professor Edgard Santos. Unidade Docente Assistencial de Cardiologia. Salvador, BA, Brasil.
dc.creator.affilliationClimecar. Clinica de Cardiologia. Itaberaba, BA, Brasil.
dc.creator.affilliationFundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Medicina. Salvador, BA, Brasil / Instituto Nacional de Ciência e Tecnologia em Investigação em Imunologia. São Paulo, SP, Brasil.
dc.subject.enChagas’ disease
dc.subject.enBenznidazol treatment
dc.subject.enImmune response
dc.subject.enCytokines
dc.subject.enEchocardiographic
dc.subject.enTissue Doppler
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