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2050-01-01
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RAB-5- AND RAB-11-DEPENDENT VESICLE-TRAFFICKING PATHWAYS ARE REQUIRED FOR PLASMA MEMBRANE REPAIR AFTER ATTACK BY BACTERIAL PORE-FORMING TOXIN
Bactérias / metabolismo
Fenômenos Fisiológicos Bacterianos
Toxinas bacterianas / metabolismo
Caenorhabditis elegans / genética
Caenorhabditis elegans / metabolismo
Caenorhabditis elegans / microbiologia
Proteínas Caenorhabditis elegans / genética
Proteínas Caenorhabditis elegans / metabolismo
Membrana Celular / genética
Membrana Celular / metabolismo
Membrana Celular / microbiologia
Vesículas citoplasmáticas / genética
Vesículas citoplasmáticas / metabolismo
Endocitose
Células Epiteliais / metabolismo
Células Epiteliais / microbiologia
Proteínas de Transporte Vesicular / genética
Proteínas de Transporte Vesicular / metabolismo
Author
Affilliation
University of California. Division of Biological Sciences. Section of Cell and Developmental Biology. San Diego, CA, United States.
University of California. Division of Biological Sciences. Section of Cell and Developmental Biology. San Diego, CA, United States.
University of California. Division of Biological Sciences. Section of Cell and Developmental Biology. San Diego, CA, United States.
University of California. Electron Microscope Lab. Berkeley, CA, United States.
University of California. Division of Biological Sciences. Section of Cell and Developmental Biology. San Diego, CA, United States.
Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Laboratório de Ultraestrutura. Recife, PE, Brasil / Centro de Tecnologias Estratégicas do Nordeste (CETENE). Laboratório de Microscopia e Microanálise. Recife, PE, Brasil.
University of California. Division of Biological Sciences. Section of Cell and Developmental Biology. San Diego, CA, United States.
University of California. Division of Biological Sciences. Section of Cell and Developmental Biology. San Diego, CA, United States.
University of California. Division of Biological Sciences. Section of Cell and Developmental Biology. San Diego, CA, United States.
University of California. Electron Microscope Lab. Berkeley, CA, United States.
University of California. Division of Biological Sciences. Section of Cell and Developmental Biology. San Diego, CA, United States.
Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Laboratório de Ultraestrutura. Recife, PE, Brasil / Centro de Tecnologias Estratégicas do Nordeste (CETENE). Laboratório de Microscopia e Microanálise. Recife, PE, Brasil.
University of California. Division of Biological Sciences. Section of Cell and Developmental Biology. San Diego, CA, United States.
Abstract
Pore-forming toxins (PFTs) secreted by pathogenic bacteria are the most common bacterial protein toxins and are important virulence factors for infection. PFTs punch holes in host cell plasma membranes, and although cells can counteract the resulting membrane damage, the underlying mechanisms at play remain unclear. Using Caenorhabditis elegans as a model, we demonstrate in vivo and in an intact epithelium that intestinal cells respond to PFTs by increasing levels of endocytosis, dependent upon RAB-5 and RAB-11, which are master regulators of endocytic and exocytic events. Furthermore, we find that RAB-5 and RAB-11 are required for protection against PFT and to restore integrity to the plasma membrane. One physical mechanism involved is the RAB-11-dependent expulsion of microvilli from the apical side of the intestinal epithelial cells. Specific vesicle-trafficking pathways thus protect cells against an attack by PFTs on plasma membrane integrity, via altered plasma membrane dynamics.
DeCS
AnimaisBactérias / metabolismo
Fenômenos Fisiológicos Bacterianos
Toxinas bacterianas / metabolismo
Caenorhabditis elegans / genética
Caenorhabditis elegans / metabolismo
Caenorhabditis elegans / microbiologia
Proteínas Caenorhabditis elegans / genética
Proteínas Caenorhabditis elegans / metabolismo
Membrana Celular / genética
Membrana Celular / metabolismo
Membrana Celular / microbiologia
Vesículas citoplasmáticas / genética
Vesículas citoplasmáticas / metabolismo
Endocitose
Células Epiteliais / metabolismo
Células Epiteliais / microbiologia
Proteínas de Transporte Vesicular / genética
Proteínas de Transporte Vesicular / metabolismo
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