| Author | Bandeira, Elga | |
| Author | Oliveira, Helena | |
| Author | Silva, Johnatas D. | |
| Author | Menna-Barreto, Rubem F. S. | |
| Author | Takya, Christina M. | |
| Author | Suk, Jung S. | |
| Author | Witwer, Kenneth W. | |
| Author | Paulaitis, Michael E. | |
| Author | Hanes, Justin | |
| Author | Rocco, Patricia R. M. | |
| Author | Morales, Marcelo M. | |
| Access date | 2019-01-29T13:47:37Z | |
| Available date | 2019-01-29T13:47:37Z | |
| Document date | 2018 | |
| Citation | BANDEIRA, Elga; et al. Therapeutic effects of adipose-tissue-derived mesenchymal stromal cells and their extracellular vesicles in experimental silicosis. Respiratory Research, v.19, n.104, 10p, 2018. | pt_BR |
| ISSN | 1465-9921 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/31338 | |
| Language | eng | pt_BR |
| Publisher | BMC | pt_BR |
| Rights | open access | |
| Subject in Portuguese | Silicose | pt_BR |
| Subject in Portuguese | Vesículas extracelulares | pt_BR |
| Subject in Portuguese | Inflamação | pt_BR |
| Subject in Portuguese | Fibrose | pt_BR |
| Subject in Portuguese | Células Mesenquimais Estromais | pt_BR |
| Title | Therapeutic effects of adipose-tissue-derived mesenchymal stromal cells and their extracellular vesicles in experimental silicosis | pt_BR |
| Type | Article | |
| DOI | 10.1186/s12931-018-0802-3 | |
| Abstract | Silicosis is an occupational disease that affects workers who inhale silica particles, leading to extensive
lung fibrosis and ultimately causing respiratory failure. Mesenchymal stromal cells (MSCs) have been shown to exert
therapeutic effects in lung diseases and represent an alternative treatment for silicosis. Recently, it has been
suggested that similar effects can be achieved by the therapeutic use of extracellular vesicles (EVs) obtained from
MSCs. The aim of this study was to investigate the effects of adipose-tissue-derived MSCs (AD-MSCs) or their EVs in
a model of silicosis. | pt_BR |
| Affilliation | Universidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Rio de Janeiro, RJ, Brasil / The Johns Hopkins University School of Medicine. Center for Nanomedicine. Baltimore, MD, USA. | pt_BR |
| Affilliation | Universidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Universidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ. Brasil. | pt_BR |
| Affilliation | Universidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | The Johns Hopkins University School of Medicine. Center for Nanomedicine. Baltimore, MD, USA. | pt_BR |
| Affilliation | The Johns Hopkins University School of Medicine. Departments of Molecular and Comparative Pathobiology and Neurology. Baltimore, MD, USA. | pt_BR |
| Affilliation | The Johns Hopkins University School of Medicine. Center for Nanomedicine. Baltimore, MD, USA. | pt_BR |
| Affilliation | The Johns Hopkins University School of Medicine. Center for Nanomedicine. Baltimore, MD, USA. | pt_BR |
| Affilliation | Universidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Universidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Rio de Janeiro, RJ, Brasil / Universidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Laboratório de Fisiologia Molecular e Celular. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Subject | Silicosis | pt_BR |
| Subject | Mesenchymal stromal cells | pt_BR |
| Subject | Inflammation | pt_BR |
| Subject | Fibrosis | pt_BR |
| Subject | Extracellular vesicles | pt_BR |
| DeCS | Células Mesenquimais Estromais | pt_BR |
| e-ISSN | 1465-993X | |
