Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/31338

Type
Article
Copyright
Open access
Collections
Share

Statistics
Metadata
Show full item record

THERAPEUTIC EFFECTS OF ADIPOSE-TISSUE-DERIVED MESENCHYMAL STROMAL CELLS AND THEIR EXTRACELLULAR VESICLES IN EXPERIMENTAL SILICOSIS
Bandeira, Elga et al. | Date Issued: 2018
Author
Bandeira, Elga
Oliveira, Helena
Silva, Johnatas D.
Menna-Barreto, Rubem F. S.
Takya, Christina M.
Suk, Jung S.
Witwer, Kenneth W.
Paulaitis, Michael E.
Hanes, Justin
Rocco, Patricia R. M.
Morales, Marcelo M.
Affilliation
Universidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Rio de Janeiro, RJ, Brasil / The Johns Hopkins University School of Medicine. Center for Nanomedicine. Baltimore, MD, USA.
Universidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Rio de Janeiro, RJ, Brasil.
Universidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ. Brasil.
Universidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Rio de Janeiro, RJ, Brasil.
The Johns Hopkins University School of Medicine. Center for Nanomedicine. Baltimore, MD, USA.
The Johns Hopkins University School of Medicine. Departments of Molecular and Comparative Pathobiology and Neurology. Baltimore, MD, USA.
The Johns Hopkins University School of Medicine. Center for Nanomedicine. Baltimore, MD, USA.
The Johns Hopkins University School of Medicine. Center for Nanomedicine. Baltimore, MD, USA.
Universidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Rio de Janeiro, RJ, Brasil.
Universidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Rio de Janeiro, RJ, Brasil / Universidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Laboratório de Fisiologia Molecular e Celular. Rio de Janeiro, RJ, Brasil.
Abstract
Silicosis is an occupational disease that affects workers who inhale silica particles, leading to extensive lung fibrosis and ultimately causing respiratory failure. Mesenchymal stromal cells (MSCs) have been shown to exert therapeutic effects in lung diseases and represent an alternative treatment for silicosis. Recently, it has been suggested that similar effects can be achieved by the therapeutic use of extracellular vesicles (EVs) obtained from MSCs. The aim of this study was to investigate the effects of adipose-tissue-derived MSCs (AD-MSCs) or their EVs in a model of silicosis.
Keywords in Portuguese
Silicose
Vesículas extracelulares
Inflamação
Fibrose
Células Mesenquimais Estromais
 
Keywords
Silicosis
Mesenchymal stromal cells
Inflammation
Fibrosis
Extracellular vesicles
 
DeCS
Células Mesenquimais Estromais
Publisher
BMC
Citation
BANDEIRA, Elga; et al. Therapeutic effects of adipose-tissue-derived mesenchymal stromal cells and their extracellular vesicles in experimental silicosis. Respiratory Research, v.19, n.104, 10p, 2018.
DOI
10.1186/s12931-018-0802-3
ISSN
1465-9921