Please use this identifier to cite or link to this item:
https://www.arca.fiocruz.br/handle/icict/31349
Type
ArticleCopyright
Open access
Collections
- IOC - Artigos de Periódicos [12977]
Metadata
Show full item record13
CITATIONS
13
Total citations
4
Recent citations
1.84
Field Citation Ratio
0.43
Relative Citation Ratio
ORAL VERSUS INTRAGASTRIC INOCULATION: SIMILAR PATHWAYS OF TRYPANOSOMA CRUZI EXPERIMENTAL INFECTION? FROM TARGET TISSUES, PARASITE EVASION, AND IMMUNE RESPONSE
Cavidade oral
Iinfecção intragástrica
Resposta imune
Ativação das Células T
Affilliation
University of Bern. Theodor Kocher Institute. Bern, Switzerland.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa sobre o Timo. Rio de Janeiro, RJ. Brasil.
University of Bern. Theodor Kocher Institute. Bern, Switzerland.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa sobre o Timo. Rio de Janeiro, RJ. Brasil / Instituto Nacional de Ciência e Tecnologia em Neuroimunomodulação. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa sobre o Timo. Rio de Janeiro, RJ. Brasil.
University of Bern. Theodor Kocher Institute. Bern, Switzerland.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa sobre o Timo. Rio de Janeiro, RJ. Brasil / Instituto Nacional de Ciência e Tecnologia em Neuroimunomodulação. Rio de Janeiro, RJ, Brasil.
Abstract
Currently, oral infection is the most frequent transmission mechanism of Chagas disease in Brazil and others Latin American countries. This transmission pathway presents increased mortality rate in the first 2 weeks, which is higher than the calculated mortality after the biting of infected insect vectors. Thus, the oral route of Trypanosoma cruzi infection, and the consequences in the host must be taken into account when thinking on the mechanisms underlying the natural history of the disease. Distinct routes of parasite entry may differentially affect immune circuits, stimulating regional immune responses that impact on the overall profile of the host protective immunity. Experimental studies related to oral infection usually comprise inoculation in the mouth (oral infection, OI) or gavage (gastrointestinal infection, GI), being often considered as similar routes of infection. Hence, establishing a relationship between the inoculation site (OI or GI) with disease progression and the mounting of T. cruzi-specific regional immune responses is an important issue to be considered. Here, we provide a discussion on studies performed in OI and GI in experimental models of acute infections, including T. cruzi infection.
Keywords in Portuguese
Trypanosoma cruziCavidade oral
Iinfecção intragástrica
Resposta imune
Ativação das Células T
Share