Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/31425
Title: Viral detection profile in children with severe acute respiratory infection
Authors: Canela, Luciana Nascimento Pinto
Barbosa, Maria Clara de Magalhães
Raymundo, Carlos Eduardo
Carney, Sharon
Siqueira, Marilda Mendonca
Barbosa, Arnaldo Prata
Cunha, Antonio José Ledo Alves da
Affilliation: Universidade Federal do Rio de Janeiro. Faculdade de Medicina. Rio de Janeiro, RJ, Brasil.
Instituto D’Or de Pesquisa e Ensino. Rio de Janeiro, RJ, Brasil.
Instituto D’Or de Pesquisa e Ensino. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Vírus Respiratórios e do Sarampo. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Vírus Respiratórios e do Sarampo. Rio de Janeiro, RJ, Brasil.
Instituto D’Or de Pesquisa e Ensino. Rio de Janeiro, RJ, Brasil / Universidade Federal do Rio de Janeiro. Faculdade de Medicina. Departamento de Pediatria. Rio de Janeiro, RJ, Brasil.
Universidade Federal do Rio de Janeiro. Faculdade de Medicina. Departamento de Pediatria. Rio de Janeiro, RJ, Brasil.
Abstract: Objectives: The role of viral co-detection in children with severe acute respiratory infection is not clear. We described the viral detection profile and its association with clinical characteristics in children admitted to the Pediatric Intensive Care Unit (PICU) during the 2009 influenza A(H1N1) pandemic. Method: Longitudinal observational retrospective study, with patients aged 0–18 years, admitted to 11 PICUs in Rio de Janeiro, with suspected H1N1 infection, from June to November, 2009. The results of respiratory samples which were sent to the Laboratory of Fiocruz/RJ and clinical data extracted from specific forms were analyzed. Results: Of 71 samples, 38% tested positive for H1N1 virus. Of the 63 samples tested for other viruses, 58 were positive: influenza H1N1 (43.1% of positive samples), rhinovirus/enterovirus (41.4%), respiratory syncytial vírus (12.1%), human metapneumovirus (12.1%), adenovirus (6.9%), and bocavirus (3.5%). Viral codetection occured in 22.4% of the cases. H1N1-positive patients were of a higher median age, had higher frequency of fever, cough and tachypnea, and decreased leukometry when compared to H1N1-negative patients. There was no difference in relation to severity outcomes (number of organic dysfunctions, use of mechanical ventilation or amines, hospital/PICU length of stay or death). Comparing the groups with mono-detection and co-dection of any virus, no difference was found regarding the association with any clinical variable. Conclusions: Other viruses can be implicated in SARI in children. The role of viral codetection has not yet been completely elucidated.
Keywords: Pandemic H1N1 Influenza
Co-detection
Pediatric intensive care unit
Severe acute respiratory infection
Child
keywords: Criança
Co-detecção
Unidade de terapia intensiva pediátrica
Infecção respiratória aguda grave
Influenza Pandemia H1N1
Issue Date: 2018
Publisher: Sociedade Brasileira de Infectologia
Citation: CANELA, Luciana Nascimento Pinto et al. Viral detection profile in children with severe acute respiratory infection. The Brazilian Journal of Infectious Diseases, v. 22, n. 5, p. 402-411, Oct. 2018.
DOI: 10.1016/j.bjid.2018.09.001
ISSN: 1413-8670
Copyright: restricted access
Appears in Collections:IOC - Artigos de Periódicos

Files in This Item:
File Description SizeFormat 
sharon_carney_etal_IOC_2018.pdf325.55 kBAdobe PDF    Request a copy



FacebookTwitterDeliciousLinkedInGoogle BookmarksBibTex Format mendeley Endnote DiggMySpace

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.