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EVALUATION OF THE CUTANEOUS LYMPHOMA INTERNATIONAL PROGNOSTIC INDEX IN PATIENTS WITH EARLY STAGE MYCOSIS FUNGOIDES
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Universidade Federal do Rio de Janeiro. Faculdade de Medicina. Hospital Universitário Clementino Fraga Filho. Rio de Janeiro, RJ, Brasil / Universidade do Sul de Santa Catarina. Faculdade de Medicina. Outpatient clinic of Dermatology. Palhoça, SC, Brasil.
Universidade Federal do Rio de Janeiro. Hospital Universitário Clementino Fraga Filho. Dermatology Division. Rio de Janeiro, RJ, Brasil.
Hospital Federal de Bonsucesso. Pathology Division. Rio de Janeiro, RJ, Brazil / Universidade Federal do Rio de Janeiro. Department of Pathology. Rio de Janeiro, RJ, Brazil.
Universidade Federal do Rio de Janeiro. Department of Pathology. Rio de Janeiro, RJ, Brazil / Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.
Universidade Federal do Rio de Janeiro. Hospital Universitário Clementino Fraga Filho. Dermatology Division. Rio de Janeiro, RJ, Brasil / Universidade Federal do Rio de Janeiro. Faculdade de Medicina. Discipline of Dermatology. Rio de Janeiro, RJ, Brazil.
Universidade Federal do Rio de Janeiro. Hospital Universitário Clementino Fraga Filho. Dermatology Division. Rio de Janeiro, RJ, Brasil.
Hospital Federal de Bonsucesso. Pathology Division. Rio de Janeiro, RJ, Brazil / Universidade Federal do Rio de Janeiro. Department of Pathology. Rio de Janeiro, RJ, Brazil.
Universidade Federal do Rio de Janeiro. Department of Pathology. Rio de Janeiro, RJ, Brazil / Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.
Universidade Federal do Rio de Janeiro. Hospital Universitário Clementino Fraga Filho. Dermatology Division. Rio de Janeiro, RJ, Brasil / Universidade Federal do Rio de Janeiro. Faculdade de Medicina. Discipline of Dermatology. Rio de Janeiro, RJ, Brazil.
Abstract
Background: Mycosis fungoides (MF) is the most common subtype of cutaneous T-cell lymphoma. TNMB system is the staging method used in MF, and it not only guides therapeutic management, but represents the main prognostic factor. In order to improve the prognostic evaluation, the Cutaneous Lymphoma International Prognostic Index (CLIPi) was proposed.
Objective: To evaluate the performance of CLIPi score for prognostic analysis in patients with early stage MF.
Methods: This is a retrospective cross-sectional observational study, with exploratory analysis. The outcome variables were disease progression and related death.
Results: One hundred and two patients were stratified according to CLIPi score, being the majority classified as low risk. Patients with intermediate or high risk presented disease progression more frequently than those with low risk (PR: 1.2 / p =0.004 / 95%CI: 1.0 – 1.6). The same did not occur with the variable related death. In addition, survival rates were not consistent with risk stratification.
Study Limitations: Small sample and its retrospective analysis.
Conclusions: Since CLIPi score was proposed, four other studies that we could consult showed conflicting results, similar to the present study. Further studies are necessary for a recommendation of its use.
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