| Author | Bongertz, Vera | |
| Author | Costa, Catia I. | |
| Author | Veloso, Valdiléa G. | |
| Author | João Filho, Esaú C. | |
| Author | Galvão-Castro, Bernardo | |
| Author | Morgado, Mariza G. | |
| Author | Hospital Evandro Chagas AIDS Clinical Research Group | |
| Access date | 2019-02-11T17:32:48Z | |
| Available date | 2019-02-11T17:32:48Z | |
| Document date | 1997 | |
| Citation | BONGERTZ, Vera et al. Correlation between susceptibility of primary HIV-1 isolates to autologous and heterologous neutralizing antibodies. AIDS, v. 11, n. 8 p. 969-975, 1997. | pt_BR |
| ISSN | 0269-9370 | pt_BR |
| xmlui.metadata.dc.identifier.other | 9223730 | |
| URI | https://www.arca.fiocruz.br/handle/icict/31547 | |
| Description | Hospital Evandro Chagas AIDS Clinical Research Group: S. Cavalcante; M. C. G. Galhardo; M. R. C. Guimarães; B. Grinsztejn and V. C. Rolla. | pt_BR |
| Language | eng | pt_BR |
| Publisher | Rapid Science Publishers | Lippincott-Raven Publishers | pt_BR |
| Rights | restricted access | |
| Title | Correlation between susceptibility of primary HIV-1 isolates to autologous and heterologous neutralizing antibodies | pt_BR |
| Type | Article | |
| Abstract | OBJECTIVE: To study the susceptibility of primary HIV-1 isolates towards autologous and heterologous neutralizing antibodies (NAb). DESIGN: Blood was collected and primary HIV-1 isolated from individuals residing in Rio de Janeiro, Brazil, in all phases of disease. METHODS: Primary HIV-1 isolates were incubated with autologous or heterologous plasma and neutralization of infection of freshly pre-stimulated normal human peripheral blood mononuclear cells was assayed in parallel to median infectious dose determinations in the absence of antibodies. Levels of HIV-1 p24 antigen were used for evaluation of viral neutralization. RESULTS: Autologous neutralization (75%) was observed for 13 (52%) out of 25 of the primary HIV-1 isolates, and 15 (71%) out of 21 isolates were susceptible to 75% heterologous neutralization by at least one-half of the heterologous plasma tested. Primary HIV-1 isolates susceptible to autologous NAb showed a higher susceptibility towards neutralization by heterologous NAb than isolates that could not be neutralized by the autologous plasma (P = 0.049). The susceptibility of the primary HIV-1 isolates towards neutralization by heterologous NAb was significantly higher for isolates derived from men (P = 0.001), and for isolates obtained from individuals infected through homo-/bisexual risk behaviour in comparison with those infected through heterosexual HIV-1 transmission (P = 0.03). CONCLUSIONS: Susceptibility of primary HIV-1 isolates to autologous and heterologous neutralization was significantly correlated, indicating that escape mutants may become resistant not only to autologous but also to heterologous NAb. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Imunologia. Laboratório de AIDS e Imunologia Molecular. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Imunologia. Laboratório de AIDS e Imunologia Molecular. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em DST/AIDS. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Hospital dos Servidos do Estado do Rio de Janeiro. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório Avançado de Saúde Pública. Salvador, BA, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Imunologia. Laboratório de AIDS e Imunologia Molecular. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Subject | Primary HIV-1 isolates | pt_BR |
| Subject | Autologous neutralization | pt_BR |
| Subject | Heterologous neutralization | pt_BR |
| Embargo date | 2050-01-01 | |
