| Author | Sacchi, Flávia Patussi Correia | |
| Author | Tatara, Mariana Bento | |
| Author | Lima, Camila Camioli de | |
| Author | Silva, Liliane Ferreia da | |
| Author | Cunha, Eunice Atsuko | |
| Author | Simonsen, Vera | |
| Author | Ferrazoli, Lucilaine | |
| Author | Gomes, Harrison Magdinier | |
| Author | Vasconcellos, Sidra Ezidio Gonçalves | |
| Author | Suffys, Philip Noel | |
| Author | Andrews, Jason R. | |
| Author | Croda, Julio | |
| Access date | 2019-02-13T12:08:19Z | |
| Available date | 2019-02-13T12:08:19Z | |
| Document date | 2018 | |
| Citation | SACCHI, Flávia Patussi Correia; et al. Genetic Clustering of Tuberculosis in an Indigenous Community of Brazil. Am. J. Trop. Med. Hyg., v.98, n.2, p.373-375, 2018. | pt_BR |
| ISSN | 0002-9637 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/31589 | |
| Language | eng | pt_BR |
| Publisher | American Society of Tropical Medicine and Hygiene | pt_BR |
| Rights | restricted access | |
| Subject in Portuguese | Tuberculose | pt_BR |
| Subject in Portuguese | Comunidade Indígena | pt_BR |
| Subject in Portuguese | Brasil | pt_BR |
| Subject in Portuguese | Agrupamento genético | pt_BR |
| Title | Genetic Clustering of Tuberculosis in an Indigenous Community of Brazil | pt_BR |
| Type | Article | |
| DOI | 10.4269/ajtmh.17-0480 | |
| Abstract | We conducted a population-based study of tuberculosis (TB) from 2009 to 2015 in an indigenous community of Brazil, the largest in the country, to investigate risk factors associated with recent TB transmission. The clinical isolates of Mycobacterium tuberculosis were genotyped by IS6110-RFLP (restriction fragment length polymorphism) and spoligotyping analysis. Among 67 isolates typed by RFLP, 69% fell into fifteen clusters, and 91% of TB cases with shared IS6110-RFLP pattern were diagnosed within 2 years of another case in the cluster. Individual risk factors associated with genetic clustering were domestic overcrowding (odds ratio [OR]: 6.10; 95% confidence interval [CI]: 1.50-24.88) and low social class (OR: 3.72; 95% CI: 1.00-13.98). Most reported contacts (76%) were identified within the household of the index TB case, but most of the genetic clustering of M. tuberculosis occurred outside of household (79%). Expanded contacts investigation and prophylaxis outside of household should be considered as a priority for TB control programs in this population. | pt_BR |
| Affilliation | Universidade Federal de Grande Dourados. Dourados, MS, Brasil. | pt_BR |
| Affilliation | Universidade Federal de Grande Dourados. Dourados, MS, Brasil. | pt_BR |
| Affilliation | Universidade Federal de Grande Dourados. Dourados, MS, Brasil. | pt_BR |
| Affilliation | Secretaria de saúde Indígena. Dourados, MS, Brasil. | pt_BR |
| Affilliation | Laboratório Central de Saúde Pública. Microbacteriologia. Campo Grande, MS, Brasil. | pt_BR |
| Affilliation | Instituto Adolfo Lutz. São Paulo, SP, Brasil. | pt_BR |
| Affilliation | Instituto Adolfo Lutz. São Paulo, SP, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Stanford University School of Medicine. Stanford, CA, USA. | pt_BR |
| Affilliation | Universidade Federal de Grande Dourados. Dourados, MS, Brasil / Fundação Oswaldo Cruz. Campo Grande, MS, Brasil. | pt_BR |
| Subject | Tuberculosis | pt_BR |
| Subject | Indigenous community | pt_BR |
| Subject | Brazil | pt_BR |
| Subject | Genetic clustering | pt_BR |
| e-ISSN | 1476-1645 | |
| Embargo date | 2030-01-01 | |
| xmlui.metadata.dc.subject.ods | 16 Paz, Justiça e Instituições Eficazes | |
