Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/31589
Title: Genetic Clustering of Tuberculosis in an Indigenous Community of Brazil
Authors: Sacchi, Flávia Patussi Correia
Tatara, Mariana Bento
Lima, Camila Camioli de
Silva, Liliane Ferreia da
Cunha, Eunice Atsuko
Simonsen, Vera
Ferrazoli, Lucilaine
Gomes, Harrison Magdinier
Vasconcellos, Sidra Ezidio Gonçalves
Suffys, Philip Noel
Andrews, Jason R.
Croda, Julio
Affilliation: Universidade Federal de Grande Dourados. Dourados, MS, Brasil.
Universidade Federal de Grande Dourados. Dourados, MS, Brasil.
Universidade Federal de Grande Dourados. Dourados, MS, Brasil.
Secretaria de saúde Indígena. Dourados, MS, Brasil.
Laboratório Central de Saúde Pública. Microbacteriologia. Campo Grande, MS, Brasil.
Instituto Adolfo Lutz. São Paulo, SP, Brasil.
Instituto Adolfo Lutz. São Paulo, SP, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil.
Stanford University School of Medicine. Stanford, CA, USA.
Universidade Federal de Grande Dourados. Dourados, MS, Brasil / Fundação Oswaldo Cruz. Campo Grande, MS, Brasil.
Abstract: We conducted a population-based study of tuberculosis (TB) from 2009 to 2015 in an indigenous community of Brazil, the largest in the country, to investigate risk factors associated with recent TB transmission. The clinical isolates of Mycobacterium tuberculosis were genotyped by IS6110-RFLP (restriction fragment length polymorphism) and spoligotyping analysis. Among 67 isolates typed by RFLP, 69% fell into fifteen clusters, and 91% of TB cases with shared IS6110-RFLP pattern were diagnosed within 2 years of another case in the cluster. Individual risk factors associated with genetic clustering were domestic overcrowding (odds ratio [OR]: 6.10; 95% confidence interval [CI]: 1.50-24.88) and low social class (OR: 3.72; 95% CI: 1.00-13.98). Most reported contacts (76%) were identified within the household of the index TB case, but most of the genetic clustering of M. tuberculosis occurred outside of household (79%). Expanded contacts investigation and prophylaxis outside of household should be considered as a priority for TB control programs in this population.
Keywords: Tuberculosis
Indigenous community
Brazil
Genetic clustering
keywords: Tuberculose
Comunidade Indígena
Brasil
Agrupamento genético
Issue Date: 2018
Publisher: American Society of Tropical Medicine and Hygiene
Citation: SACCHI, Flávia Patussi Correia; et al. Genetic Clustering of Tuberculosis in an Indigenous Community of Brazil. Am. J. Trop. Med. Hyg., v.98, n.2, p.373-375, 2018.
DOI: 10.4269/ajtmh.17-0480
ISSN: 0002-9637
Copyright: restricted access
Appears in Collections:IOC - Artigos de Periódicos

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