Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/31647
Title: Spectrum of Morphologic Changes of Lymph Nodes in HIV Infection
Authors: Paiva, D. D.
Morais, J. C.
Pilotto, José H. P.
Veloso, Valdiléa G.
Duarte, F.
Lenzi, H. L.
Affilliation: Universidade do Estado do Rio de Janeiro. Faculdade de Medicina. Departamento de Patologia e Laboratórios. Serviço de Anatomia Patológica. Rio de Janeiro, RJ, Brasil.
Departamento de Patologia. Serviço de Anatomia Patológica. Rio de Janeiro, RJ, Brasil.
Universidade do Estado do Rio de Janeiro. Hospital Universitário Clementino Fraga Filho. Serviço de Doenças Infecciosas e Parasitárias. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em DST/AIDS./ Hospital Carlos Chagas. Rio de Janeiro, RJ, Brasil.
Departamento de Patologia. Serviço de Anatomia Patológica. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Patologia. Rio de Janeiro, RJ, Brasil.
Abstract: Cervical lymph nodes biopsies from 31 HIV positive patients (with or without AIDS) were studied by histologic methods and immunohistochemistry (StreptABC staining of paraffin sections) to identify cellular and extracellular matrix components. The results were the following: (1) the biopsies were included in the stages of follicular hyperplasia without fragmentation FH-FF (4 cases); follicular hyperplasia with follicular fragmentation FH + FF (16 cases); follicular involution FI (6 cases) and diffuse pattern DP (5 cases); (2) the most important alteration was the germinal centers disruption due to follicle lysis, which began in the light zone; (3) there was coincidence between intrafollicular hemorrhages and segmental hyaline mycroangiopathy; (4) during the progression of the disease occurred; (a) an increase in the number of mast cells, CD68+ and Mac 387+ macrophages; (b) a diffuse augment of collagen III, elastic fibers, laminin, fibronectin and proteoglycans; (c) maintenance of Factor VIII-related antigens in the vascular endothelial cells, with decrease in the expression of Ulex-Europeus I lectin. Follicular hyperplasia (FH - FF or FH + FF) was the most common histologic pattern recognized in the lymph nodes of patients without AIDS and follicular involution and difuse pattern were seen in those who had AIDS. The results indicate that the lymph node biopsies may provide important information about the evolutive stage of the disease and its prognosis.
Keywords: Lymph node
HIV
AIDS
Extracellular matrix
Mast cells
Mycroangiopathy
Issue Date: 1996
Publisher: Instituto Oswaldo Cruz
Citation: PAIVA, D. D. et al. Spectrum of Morphologic Changes of Lymph Nodes in HIV Infection. Memórias do Instituto Oswaldo Cruz, v. 91, n. 3, p. 371-379, 1996.
Description: FIRST BRAZILIAN SYMPOSIUM ON BASIC RESEARCH IN HIV/ AIDS
DOI: 10.1590/S0074-02761996000300023
ISSN: 1678-8060
Copyright: open access
Appears in Collections:INI - Artigos de Periódicos

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