Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/31684
Title: Chlamydia trachomatis asymptomatic urethritis recurrence among males living with HIV-1
Authors: Silva, Guilherme Almeida Rosa da
Motta, Heloisa Loureiro de Sá Neves
Souza, Erik Friedrich Alex de
Cardoso, Pedro Afonso Nogueira Moises
Pilotto, José Henrique
Silva, Walter Araujo Eyer
Ribeiro, Luiz Cláudio Pereira
Santos, Mônica Soares dos
Azevedo, Marcelo Costa Velho Mendes de
Pinto, Jorge Francisco da Cunha
Motta, Rogerio Neves
Ferry, Fernando Raphael de Almeida
Affilliation: Universidade Federal do Estado do Rio de Janeiro. Serviço de Clínica Médica. 10ª Enfermaria. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de AIDS e Imunologia Molecular. Rio de Janeiro, RJ, Brasil.
Universidade Federal do Estado do Rio de Janeiro. Serviço de Clínica Médica. 10ª Enfermaria. Rio de Janeiro, RJ, Brasil.
Universidade Federal do Estado do Rio de Janeiro. Serviço de Clínica Médica. 10ª Enfermaria. Rio de Janeiro, RJ, Brasil.
Universidade Federal do Estado do Rio de Janeiro. Serviço de Clínica Médica. 10ª Enfermaria. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Laboratório de AIDS e Imunologia Molecular. Rio de Janeiro, RJ, Brasil.
Universidade Federal do Estado do Rio de Janeiro. Centro de Ciências Biológicas e da Saúde. Rio de Janeiro, RJ, Brasil.
Universidade Federal do Estado do Rio de Janeiro. Hospital Universitário Gaffrée e Guinle. Laboratório de Imunologia. Rio de Janeiro, RJ, Brasil.
Universidade Federal do Estado do Rio de Janeiro. Hospital Universitário Gaffrée e Guinle. Laboratório de Imunologia. Rio de Janeiro, RJ, Brasil.
Universidade Federal do Estado do Rio de Janeiro. Serviço de Clínica Médica. 10ª Enfermaria. Rio de Janeiro, RJ, Brasil.
Universidade Federal do Estado do Rio de Janeiro. Serviço de Clínica Médica. 10ª Enfermaria. Rio de Janeiro, RJ, Brasil.
Universidade Federal do Estado do Rio de Janeiro. Serviço de Clínica Médica. 10ª Enfermaria. Rio de Janeiro, RJ, Brasil.
Universidade Federal do Estado do Rio de Janeiro. Serviço de Clínica Médica. 10ª Enfermaria. Rio de Janeiro, RJ, Brasil.
Abstract: A prevalence of 3.47% of asymptomatic Chlamydia trachomatis urethritis has been previously reported among males living with HIV infection in Brazil. This study aims to assess the recurrence of C. trachomatis urethritis three years later in the same cohort of patients and analyze associated risk factors. A total of 115 male patients diagnosed with HIV infection, with no symptoms of urethritis and observed since May of 2015 in followup visits were enrolled. They had urine samplers tested by PCR for C. trachomatis and N. gonorrhoeae between February and March 2018. Results: Three of the four patients who had asymptomatic C. trachomatis urethritis three years before were recurrently positive for C. trachomatis urethritis. Two new patients were diagnosed as positives, accounting for a total asymptomatic C. trachomatis urethritis prevalence of 4.34%. The prevalence during the whole study was 5.21%. The relative risk for a new urethritis episode among those previously diagnosed with urethritis is RR=41.62 (95% CI: 9.42-183.84), p < 0.01. Patients who presented asymptomatic urethritis anytime and who were recurrently positive for C. trachomatis had a lower mean age (p<0.01). Married individuals were protected regarding asymptomatic urethritis [p<0.01, OR = 0.04 (0.005-0.4)] and had lower risk to develop recurrence [p<0.01, RR = 0.86 (0.74-0.99)]. Illicit drugs users had risk associated to asymptomatic urethritis [p=0.02, OR= 5.9 (1.03-34)] and higher risk to develop recurrence [p<0.01, RR=1.1 (1-1.22)]. Conclusion: The recurrence of asymptomatic C. trachomatis urethritis after treatment among males living with HIV infection in Brazil can be considered high and should not be neglected.
Keywords: HIV
AIDS
Neisseria gonorrhoeae
Chlamydia trachomatis
Urethritis
keywords: HIV
AIDS
Uretrite
Chlamydia trachomatis
Neisseria gonorrhoeae
Issue Date: 2018
Publisher: Universidade de São Paulo
Citation: SILVA, Guilherme Amleida da Rosa e et al. Chlamydia trachomatis asymptomatic urethritis recurrence among males living with HIV-1. Rev. Inst. Med. Trop., São Paulo, v. 60, p. 1-5, 2018.
DOI: 10.1590/S1678-9946201860065
ISSN: 0036-4665
Copyright: open access
Appears in Collections:IOC - Artigos de Periódicos

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