ADCC-Mediated CD56DIM NK Cell Responses Are Associated with Early HBsAg Clearance in Acute HBV Infection

The Ragon Institute of MGH, MIT, and Harvard, Cambridge, Massachusetts. USA / Massachusetts Institute of Technology. Department of Biological Engineering. Cambridge, Massachussets, USA.
The Ragon Institute of MGH, MIT, and Harvard, Cambridge, Massachusetts. USA.
University Hospital Basel. Dept. of Biomedicine. Basel, Switzerland.
The Ragon Institute of MGH, MIT, and Harvard, Cambridge, Massachusetts. USA.
The Ragon Institute of MGH, MIT, and Harvard, Cambridge, Massachusetts. USA.
Massachusetts General Hospital, Boston, Massachusetts, USA.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ. Brasil.
Massachusetts General Hospital, Boston, Massachusetts, USA.
The Ragon Institute of MGH, MIT, and Harvard, Cambridge, Massachusetts. USA.

Abstract

Hepatitis B virus (HBV) affects up to 400 million people worldwide and accounts for approximately one million deaths per year from liver pathologies. Current treatment regimens are effective in suppressing viremia but usually have to be taken indefinitely, warranting research into new therapeutic approaches. Acute HBV infection in adults almost universally results in resolution of viremia, with the exception of immunocompromised persons, suggesting that the immune response can functionally cure or even eradicate HBV infection.

Publisher

Case Western Reserve University

Citation

YOU, Wen-Han et al. ADCC-Mediated CD56DIM NK Cell Responses are Associated with early HBsAg Clearence in Acute HBV Infection. Pathogens and Immunity, v. 3, n. 1, p.1-2, Feb. 2018.

DOI

10.20411/pai.v3i1.228

ISSN

2469-2964

Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/31759

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Case Western Reserve University

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