Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/31791
Title: Characterization of the clonal subpopulation Fiocruz L1-130 of Leptospira interrogans in rats and dogs from Brazil
Authors: Jaeger, Lauren Hubert
Pestana, Cristiane Pinheiro
Costa, Filipe Anibal Carvalho
Medeiros, Marco Alberto
Lilenbaum, Walter
Affilliation: Universidade Federal Fluminense. Departamento de Microbiologia e Parasitologia. Laboratório de Epidemeiologia e Sistemática Molecular. Niterói, RJ, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Epidemiologia e Sistemática Molecular. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Biomanguinhos. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Epidemiologia e Sistemática Molecular. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Biomanguinhos. Rio de Janeiro, RJ, Brasil.
Universidade Federal Fluminense. Departamento de Microbiologia e Parasitologia. Laboratório de Epidemeiologia e Sistemática Molecular. Niterói, RJ, Brasil.
Abstract: Purpose. Leptospira interrogans serogroup Icterohaemorrhagiae strains have been described as causing disease in both humans and animals and as being present worldwide. Icterohaemorrhagiae and Copenhageni serovars are known to cause severe disease in their hosts, and zoonotic outbreaks have been described. The genetic similarity among the strains of these serovars is known. However, it has not yet been demonstrated whether major clonal subpopulation in humans, strain Fiocruz L1-130-like, can circulate among other hosts. Methodology. We performed genetic characterization of Brazilian serogroup Icterohaemorrhagiae strains of dog and rat origin by secY sequencing, variable-number tandem-repeat, multilocus sequence type and multi-spacer typing analysis. Results. The strains were found to be identical among themselves and to strain Fiocruz L1-130. We suggest that the major strain of L. interrogans serogroup Icterohaemorrhagiae, Fiocruz L1-130, is widely distributed in Brazil in different hosts with substantial zoonotic potential. Conclusion. Understanding the circulation of strain Fiocruz L1-130 is important for the implementation of appropriate control measures. Its circulation highlights the need to treat leptospirosis caused by L. interrogans serogroup Icterohaemorrhagiae as a zoonosis that acts in the human–animal–environment interface, as per the One Health approach.
Keywords: Leptospira interrogans
Characterization
Rats
Dogs
Clonal subpopulation Fiocruz L1-130
keywords: Subpopulação clonal Fiocruz L1-130
Leptospira interrogans
Caracterização
Cães
Gatos
Brasil
Issue Date: 2018
Publisher: Microbiology Society
Citation: JAEGER, Lauren Hubert et al. Characterization of the clonal subpopulation Fiocruz L1-130 of Leptospira interrogans in rats and dogs from Brazil. Journal of Medical Microbiology, v. 67, p. 1361-1367, 2018.
DOI: 10.1099/jmm.0.000806
ISSN: 0022-2615
Copyright: restricted access
Appears in Collections:Biomanguinhos - Artigos de Periódicos
IOC - Artigos de Periódicos

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