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ACTIVITY PROFILING OF PEPTIDASES IN ANGIOSTRONGYLUS COSTARICENSIS FIRST-STAGE LARVAE AND ADULT WORMS
Angiostrongylus costaricensis
Vermes adultos
Perfil de atividade
Larvas de primeiro estágio
Author
Affilliation
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Toxinologia. Rio de Janeiro, RJ, Brasil.
University of California. Center for Discovery and innovation in Parasitic Diseases. San Diego, La Jolla, USA / University of California San Diego. Skaggs School of Pharmacy and Pharmaceutical Sciences. La Jolla, California, USA.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Patologia. Rio de Janeiro, RJ, Brasil.
University of California. Center for Discovery and innovation in Parasitic Diseases. San Diego, La Jolla, USA / University of California San Diego. Skaggs School of Pharmacy and Pharmaceutical Sciences. La Jolla, California, USA.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Toxinologia. Rio de Janeiro, RJ, Brasil.
University of California. Center for Discovery and innovation in Parasitic Diseases. San Diego, La Jolla, USA / University of California San Diego. Skaggs School of Pharmacy and Pharmaceutical Sciences. La Jolla, California, USA.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Patologia. Rio de Janeiro, RJ, Brasil.
University of California. Center for Discovery and innovation in Parasitic Diseases. San Diego, La Jolla, USA / University of California San Diego. Skaggs School of Pharmacy and Pharmaceutical Sciences. La Jolla, California, USA.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Toxinologia. Rio de Janeiro, RJ, Brasil.
Abstract
Angiostrongylus costaricensis is a relatively uncharacterized nematode that causes abdominal angiostrongyliasis in Latin America, a human parasitic disease. Currently, no effective pharmacological treatment for angiostrongyliasis exists. Peptidases are known to be druggable targets for a variety of diseases and are essential for several biological processes in parasites. Therefore, this study aimed to systematically characterize the peptidase activity of A. costaricensis in different developmental stages of this parasitic nematode.
Keywords in Portuguese
PeptidasesAngiostrongylus costaricensis
Vermes adultos
Perfil de atividade
Larvas de primeiro estágio
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