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INCREASE IN VIRULENCE OF SPOROTHRIX BRASILIENSIS OVER FIVE YEARS IN A PATIENT WITH CHRONIC DISSEMINATED SPOROTRICHOSIS
Chitin synthase
Disseminated
Galleria mellonella
Reactive nitrogen intermediates
Rio de Janeiro
Sporothrix brasiliensis
Sporotrichosis
T3B PCR
Virulence
Author
Affilliation
Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil / Albert Einstein College of Medicine. New York, NY USA.
Albert Einstein College of Medicine. New York, NY, USA / Universidade de São Paulo. Faculdade de Ciências Farmacêuticas. São Paulo, SP, Brasil.
Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.
Albert Einstein College of Medicine. New York, NY USA.
Albert Einstein College of Medicine. New York, NY, USA / Universidade de São Paulo. Faculdade de Ciências Farmacêuticas. São Paulo, SP, Brasil.
Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.
Albert Einstein College of Medicine. New York, NY USA.
Abstract
The metropolitan region of Rio de Janeiro is hyperendemic for cat-associated sporotrichosis. This study aimed to assess the virulence of serial Sporothrix isolates from a 61-year-old male patient with chronic, destructive disseminated sporotrichosis. Five Sporothrix isolates were cultured from skin exudates and bone samples over a 5-year period, and all were molecularly identified as Sporothrix brasiliensis. The final isolate was significantly more virulent in Galleria mellonella larvae compared to earlier isolates. We conclude that S. brasiliensis has the capacity to increase in virulence in vivo. This finding is significant to clinicians caring for individuals with S. brasiliensis disease and it suggests that further studies are needed to identify the mechanisms underlying pathogenicity enhancement during chronic disease.
Keywords
BrazilChitin synthase
Disseminated
Galleria mellonella
Reactive nitrogen intermediates
Rio de Janeiro
Sporothrix brasiliensis
Sporotrichosis
T3B PCR
Virulence
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