Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/31945
Title: Single-Nucleotide Polymorphisms in NOD1, RIPK2, MICB, PLCE1, TNF, and IKBKE Genes Associated with Symptomatic Dengue in Children from Colombia
Authors: Useche, Yerly Magnolia
Ribeiro-Alves, Marcelo
Restrepo, Berta-Nelly
Salgado, Doris Martha
Narváez, Carlos Fernando
Campo, Omer
Avendaño, Efrén
Martínez, Catalina
Chacon-Duque, Juan Camilo
Bedoya, Gabriel
Affilliation: Laboratorio de Genética Molecular, Instituto de Biología, Universidad de Antioquia. Medellín, Colombia.
Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em DST/AIDS. Rio de Janeiro, RJ, Brasil.
Instituto Colombiano de Medicina Tropical ICMT, Universidad CES. Sabaneta, Colombia.
Unidad de Infectología Pediátrica, Hospital Universitario de Neiva. Neiva, Colombia./ Programa de Medicina, Facultad de Salud, Universidad Surcolombiana. Neiva, Colombia.
Programa de Medicina, Facultad de Salud, Universidad Surcolombiana. Neiva, Colombia.
Laboratorio de Genética Molecular, Instituto de Biología, Universidad de Antioquia. Medellín, Colombia.
Grupo de Ciencias Básicas Aplicadas del Tecnológico de Antioquia, Tecnológico de Antioquia-Institución Universitaria. Medellín, Colombia.
Laboratorio de Genética Molecular, Instituto de Biología, Universidad de Antioquia. Medellín, Colombia.
Department of Genetics, Evolution and Environment, University College London. London, United Kingdom.
Laboratorio de Genética Molecular, Instituto de Biología, Universidad de Antioquia. Medellín, Colombia.
Abstract: Functional immunological evidence supports the impact that the host genetic variability has on the susceptibility to develop asymptomatic or symptomatic dengue infection. Children are more prone to develop severe dengue. Thus, we have evaluated possible associations between single-nucleotide polymorphisms (SNPs) located in immune genes and the development of symptomatic dengue in children from two Colombian populations with differences in genetic backgrounds and geographical features. We genotyped 15 SNPs (in 12 genes) in 298 symptomatic children and 648 healthy controls. Ancestry proportions (APs) were inferred by genotyping 29 ancestry informative markers. We observed four SNPs associated with susceptibility to develop dengue in NOD1, RIPK2, MICB, or PLCE1 genes. Conversely, we found one SNP in TNF gene and two haplotypes in the IKBKE gene associated with resistance to develop dengue. These associations were adjusted by gender, APs, and the population of origin because the association of polymorphisms may be different in admixed populations like Colombian. To our knowledge, this is the first reported association study with dengue in IKBKE, RIPK2, and NOD1 genes. We have also confirmed previously reported associations in MICB and PLCE1 genes with dengue. Overall, our results contribute to the understanding of the genetic susceptibility/resistance to develop symptomatic dengue. Nevertheless, these associations must be validated through functional analysis.
Keywords: Dengue
MICB
NOD1
RIPK2
SNPs
IKBKE
Issue Date: 2018
Publisher: Mary Ann Lieber
Citation: USECHE, Yerly Magnolia et al.Single-Nucleotide Polymorphisms in NOD1, RIPK2, MICB, PLCE1, TNF, and IKBKE Genes Associated with Symptomatic Dengue in Children from Colombia. Viral Immunology, v. 31, n. 9, p. 613-623, 2018
DOI: 10.1089/vim.2018.0028
ISSN: 0882-8245
Copyright: restricted access
Appears in Collections:INI - Artigos de Periódicos

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