Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/31953
Title: Extract from Aphloia theiformis, an edible indigenous plant from Reunion Island, impairs Zika virus attachment to the host cell surface
Authors: Clain, Elodie
Sinigaglia, Laura
Koishi, Andrea Cristine
Gorgette, Olivier
Gadea, Gilles
Viranaicken, Wildriss
Krejbich-Trotot, Pascale
Mavingui, Patrick
Desprès, Philippe
Santos, Claudia Nunes Duarte dos
Guiraud, Pascale
Jouvenet, Nolwenn
El-Kalamouni, Chaker
Affilliation: Université de La Réunion. Processus Infectieux Insulaire Tropical. Plateforme Technologique CYROI. Sainte, Clotilde, France.
Viral Genomics and Vaccination Unit. Pasteur Institute. Paris, France.
Fundação Oswaldo Cruz. Instituto Carlos Chagas. Laboratório de Virologia Molecular. Curitiba, PR, Brasil.
Ultrastructural BioImaging (UTechsUBI). Pasteur Institute. Paris, France.
Université de La Réunion. Processus Infectieux Insulaire Tropical. Plateforme Technologique CYROI. Sainte, Clotilde, France.
Université de La Réunion. Processus Infectieux Insulaire Tropical. Plateforme Technologique CYROI. Sainte, Clotilde, France.
Université de La Réunion. Processus Infectieux Insulaire Tropical. Plateforme Technologique CYROI. Sainte, Clotilde, France.
Université de La Réunion. Processus Infectieux Insulaire Tropical. Plateforme Technologique CYROI. Sainte, Clotilde, France.
Université de La Réunion. Processus Infectieux Insulaire Tropical. Plateforme Technologique CYROI. Sainte, Clotilde, France.
Fundação Oswaldo Cruz. Instituto Carlos Chagas. Laboratório de Virologia Molecular. Curitiba, PR, Brasil.
Université de La Réunion. Processus Infectieux Insulaire Tropical. Plateforme Technologique CYROI. Sainte, Clotilde, France.
Viral Genomics and Vaccination Unit. Pasteur Institute. Paris, France.
Université de La Réunion. Processus Infectieux Insulaire Tropical. Plateforme Technologique CYROI. Sainte, Clotilde, France.
Abstract: The mosquito-borne Zika virus (ZIKV) belongs to the flavivirus genus of the Flaviviridae family. Contemporary epidemic strains of ZIKV are associated with congenital malformations in infants, including microcephaly, as well as Guillain-Barré syndrome in adults. A risk of human-to-human transmission of ZIKV is also well documented. A worldwide research effort has been undertaken to identify safe and effective strategies to prevent or treat ZIKV infection. We show here that extract from Aphloia theiformis, an edible endemic plant from Indian Ocean islands, exerts a potent antiviral effect against ZIKV strains of African and Asian lineages, including epidemic strains. The antiviral effect of A. theiformis extract was extended to clinical isolates of dengue virus (DENV) of the four serotypes in human hepatocytes. A. theiformis inhibited virus entry in host cells by acting directly on viral particles, thus impairing their attachment to the cell surface. Electron microscopic observations revealed that organization of ZIKV particles was severely affected by A. theiformis. We propose a model of antiviral action for A. theiformis against flaviviruses that highlights the potential of medicinal plants as promising sources of naturally-derived antiviral compounds to prevent ZIKV and DENV infections.
Keywords: Zika Virus Infection
Microcephaly
Aphloia theiformis
Antiviral Agents
Dengue Virus
Plants, Medicinal
Keywords in spanish: Infección por el Virus Zika
Antivirales
Virus del Dengue
Plantas Medicinales
DeCS: Infecção pelo Zika virus
Microcefalia
Antivirais
Vírus da Dengue
Plantas Medicinais
Issue Date: 2018
Publisher: Nature Research
Citation: CLAIN, Elodie et al. Extract from Aphloia theiformis, an edible indigenous plant from Reunion Island, impairs Zika virus attachment to the host cell surface. Scientific Reports, v. 8, n. 10856, 2018.
DOI: 10.1038/s41598-018-29183-2
ISSN: 2045-2322
Copyright: open access
Appears in Collections:PR - ICC - Artigos de Periódicos

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