Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/31954
Title: Arbovirus investigation in patients from Mato Grosso during Zika andChikungunya virus introdution in Brazil, 2015–2016
Authors: Costa, M. C. de Souza
Maia, L. M. Siqueira
Souza, Valdinete Costa de
Gonzaga, A. M.
Azevedo, V. Correa de
Martins, L. Ramos
Pavoni, J. H. Chavez
Naveca, Felipe Gomes
Slhessarenko, R. Dezengrini
Affilliation: Fundação Oswaldo Cruz. Instituto de Pesquisas Leônidas e Maria Deane. Manaus, AM, Brasil.
Universidade Federal de Mato Grosso. Faculdade de Medicina. Departamento de Ciências Básicas em Saúde. Programa de Pós-Graduação em Ciências da Saúde. Cuiabá, MT, Brasil.
Universidade Federal de Mato Grosso. Faculdade de Medicina. Departamento de Ciências Básicas em Saúde. Programa de Pós-Graduação em Ciências da Saúde. Cuiabá, MT, Brasil.
Fundação Oswaldo Cruz. Instituto Leônidas e Maria Deane. Manaus, AM, Brasil.
Secretaria Estadual de Saúde. LACEN-MT. Cuiabá, MT, Brasil.
Secretaria Estadual de Saúde. LACEN-MT. Cuiabá, MT, Brasil.
Universidade Federal de Mato Grosso Graduação em Medicina Veterinária. Faculdade de Medicina Veterinária. Cuiabá, MT, Brasil.
Universidade Federal de Mato Grosso. Faculdade de Medicina. Rondonópolis, MT, Brasil.
Fundação Oswaldo Cruz. Instituto Leônidas e Maria Deane. Manaus, AM, Brasil.
Universidade Federal de Mato Grosso. Faculdade de Medicina. Departamento de Ciências Básicas em Saúde. Programa de Pós-Graduação em Ciências da Saúde. Cuiabá, MT, Brasil.
Abstract: Arboviruses have become a major public health concern in Brazil, especially after Zika virus (ZIKV) and Chikungunya virus (CHIKV) introduction, leading to massive epidemics. We conducted an investigation of arboviruses in patients with acute febrile illness for less thanfive days in Mato Grosso state (MT) during the periodof ZIKV and CHIKV dissemination in Brazil. To achieve that, 453 human serum samples of patients suspected ofDengue (DENV), Yellow Fever (YFV), ZIKV or CHIKV collected in health units of 31 cities of MT were subjectedto RT-PCR protocols for 10flaviviruses, 5 alphaviruses and orthobunyaviruses from Simbu serogroup, nucleotidesequencing and viral isolation. Regardingflaviviruses,five (1.1%) patients were infected with DENV-1 genotypeV, 22 (4.4%) with DENV-4 genotype II, 3 (0.7%) with YFV South American genotype II andfive (1.1%) withZIKV Asian genotype. Thefirst human case of ZIKV in MT was detected in this study during August, 2015 in Tapurah. Alphaviruses were detected in 2 (0.4%) patients infected with CHIKV genotype ECSA, 1 (0.2%) withMadariaga (EEEV) lineage III and 34 (7.5%) with Mayaro (MAYV) genotype L. Four (11.4%) patients presenteddual infections with DENV-1/ZIKV, DENV-1/DENV4, DENV-4/MAYV and ZIKV/MAYV. The majority - 13/34positive for MAYV, one for Madariaga virus - are residents in Várzea Grande (VG), metropolitan region of Cuiabá, capital of MT. Thefirst CHIKV infection in MT was detected in this study in Mirassol D’Oeste, during July, 2015. In addition, 20 (4.4%) patients were positive for OROV Segment S genotype IA. These results re-inforce the variation in arboviruses frequency and distribution during outbreaks, highlinghing the importance ofdifferential diagnosis to identify agents silently co-circulating with major health problem arboviruses.
Keywords: Zika virus
Dengue virus
Chikungunya virus
Mayaro virus
Public health
Epidemiology
Issue Date: 2019
Citation: COSTA, M. C. de Souza et al. Arbovirus investigation in patients from Mato Grosso during Zika and Chikungunya virus introdution in Brazil, 2015–2016. Acta Tropica, Philadelfia, v. 190, p. 395-402, feb. 2019.
DOI: 10.1016/j.actatropica.2018.12.019
ISSN: 0001-706X
Copyright: restricted access
Appears in Collections:AM - ILMD - Artigos de Periódicos

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