Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/31988
Title: The yellow fever 17D virus as a platform for new live attenuated vaccines
Authors: Bonaldo, Myrna C.
Sequeira, Patrícia C.
Galler, Ricardo
Affilliation: Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Bioquímica e Biologia Molecular. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Bioquímica e Biologia Molecular. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto de Tecnologia em Imunobiológicos. Departamento de Desenvolvimento Tecnológico. Rio de Janeiro, RJ, Brasil.
Abstract: The live-attenuated yellow fever 17D virus is one of the most outstanding human vaccines ever developed. It induces efficacious immune responses at a low production cost with a well-established manufacture process. These advantages make the YF17D virus attractive as a vector for the development of new vaccines. At the beginning of vector development studies, YF17D was genetically manipulated to express other flavivirus prM and E proteins, components of the viral envelope. While these 17D recombinants are based on the substitution of equivalent YF17D genes, other antigens from unrelated pathogens have also been successfully expressed and delivered by recombinant YF17D viruses employing alternative strategies for genetic manipulation of the YF17D genome. Herein, we discuss these strategies in terms of possibilities of single epitope or larger sequence expression and the main properties of these replication-competent viral platforms.
Keywords: Yellow fever virus
17D vaccine
Recombinant viruses
Vaccine development
Foreign gene expression
keywords: Vírus da febre amarela
Vacina 17D
Expressão de genes estranhos
Vírus recombinantes
Desenvolvimento de vacinas
Issue Date: 2014
Citation: BONALDO, Myrna C.; SEQUEIRA, Patrícia C.; GALLER, Ricardo. The yellow fever 17D virus as a platform for new live attenuated vaccines. Human Vaccines & Immunotherapeutics, v. 10, n. 5, p. 1256–1265, May 2014.
Description: Artigo disponível em acesso aberto na página do editor.
DOI: 10.4161/hv.28117
ISSN: 2164-5515
Copyright: open access
Appears in Collections:IOC - Artigos de Periódicos
Biomanguinhos - Artigos de Periódicos

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