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https://www.arca.fiocruz.br/handle/icict/31988
THE YELLOW FEVER 17D VIRUS AS A PLATFORM FOR NEW LIVE ATTENUATED VACCINES
Vacina 17D
Expressão de genes estranhos
Vírus recombinantes
Desenvolvimento de vacinas
17D vaccine
Recombinant viruses
Vaccine development
Foreign gene expression
Affilliation
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Bioquímica e Biologia Molecular. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Bioquímica e Biologia Molecular. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto de Tecnologia em Imunobiológicos. Departamento de Desenvolvimento Tecnológico. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Bioquímica e Biologia Molecular. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto de Tecnologia em Imunobiológicos. Departamento de Desenvolvimento Tecnológico. Rio de Janeiro, RJ, Brasil.
Abstract
The live-attenuated yellow fever 17D virus is one of the most outstanding human vaccines ever developed. It induces efficacious immune responses at a low production cost with a well-established manufacture process. These advantages make the YF17D virus attractive as a vector for the development of new vaccines. At the beginning of vector development studies, YF17D was genetically manipulated to express other flavivirus prM and E proteins, components of the viral envelope. While these 17D recombinants are based on the substitution of equivalent YF17D genes, other antigens from unrelated pathogens have also been successfully expressed and delivered by recombinant YF17D viruses employing alternative strategies for genetic manipulation of the YF17D genome. Herein, we discuss these strategies in terms of possibilities of
single epitope or larger sequence expression and the main properties of these replication-competent viral platforms.
Keywords in Portuguese
Vírus da febre amarelaVacina 17D
Expressão de genes estranhos
Vírus recombinantes
Desenvolvimento de vacinas
Keywords
Yellow fever virus17D vaccine
Recombinant viruses
Vaccine development
Foreign gene expression
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