Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/32029
Title: Impaired immunoregulatory network of the CD4 T lymphocytes in refractory asthma
Authors: Fernandes, Jamille Souza
Araujo, Maria Ilma
Almeida, Tarcísio Vila Verde Santana de
Andrade, Lorena Silva
Lopes, Diego Marques
Mello, Luane Marques de
Carvalho Filho, Edgar Marcelino de
Cruz Filho, Álvaro Augusto Souza da
Cardoso, Luciana Santos
Affilliation: Universidade Federal do Oeste da Bahia. Centro de Ciências Biológicas e da Saúde. Barreiras, BA, Brasil / Universidade Federal da Bahia. Hospital Universitário Professor Edgard Santos. Serviço de Imunologia. Salvador, BA, Brasil / Universidade Federal da Bahia. Núcleo de Excelência em Asma. Salvador, BA, Brasil.
Universidade Federal da Bahia. Hospital Universitário Professor Edgard Santos. Serviço de Imunologia. Salvador, BA, Brasil.
Universidade Federal da Bahia. Hospital Universitário Professor Edgard Santos. Serviço de Imunologia. Salvador, BA, Brasil / Escola Bahiana de Medicina e Saúde Pública. Salvador, BA, Brasil.
Universidade Federal da Bahia. Hospital Universitário Professor Edgard Santos. Serviço de Imunologia. Salvador, BA, Brasil.
Universidade Federal da Bahia. Hospital Universitário Professor Edgard Santos. Serviço de Imunologia. Salvador, BA, Brasil.
Universidade Federal da Bahia. Núcleo de Excelência em Asma. Salvador, BA, Brasil / Faculdade de Medicina de Ribeirão Preto. Departamento de Medicina Social. Ribeirão Preto, SP, Brasil.
Universidade Federal da Bahia. Hospital Universitário Professor Edgard Santos. Serviço de Imunologia. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório de Pesquisas Clínicas. Salvador, BA, Brasil / Instituto Nacional de Ciência e Tecnologia em Doenças Tropicais. Brasília, DF, Brasil.
Universidade Federal da Bahia. Núcleo de Excelência em Asma. Salvador, BA, Brasil.
Universidade Federal da Bahia. Hospital Universitário Professor Edgard Santos. Serviço de Imunologia. Salvador, BA, Brasil / Universidade federal da Bahia. Faculdade de Farmácia. Departamento de Análises Clínicas e Toxicológicas. Salvador, BA, Brasil.
Abstract: The immunopathogenesis of severe asthma has been associated with an inefficient regulatory response. There are a few studies about the CD4 T cells profile among individuals with severe asthma refractory to treatment. Objective: To evaluate the CD4 T lymphocyte profile from individuals with severe asthma according to their response to treatment, relating to their atopy status and age of asthma onset. Methods: We evaluated nineteen individuals with severe asthma refractory to treatment (SAR), 21 with well‐controlled or partly controlled severe asthma (CSA) and 23 with mild‐to‐moderate asthma (MMA). Lymphocytes were obtained from PBMC, and the frequency of expression of different molecules in this population was assessed using the flow cytometry. Results: We observed the frequency of CD4+IFN‐γ+T cells was higher in atopic individuals with SAR than with CSA. In addition, among the atopic and early‐onset asthma (EOA), the frequency of CD4+CTLA‐4+T cells was lower in the SAR group than the CSA group. In relation to non‐atopic and late‐onset asthma (LOA) phenotypes, we noted the frequency of CD4+FoxP3+T cells was lower in individuals with SAR than with CSA. We also observed among the LOA patients, the frequency of CD4+TGF‐β+ T cells was decreased in SAR group than the in CSA group. Conclusion and Clinical Relevance: Our data suggest that refractoriness to treatment in asthma is associated with a lower expression of distinct regulatory molecules by CD4 T cells between those who are atopic and have EOA and those who are non‐atopic and have LOA. Thus, these results may contribute to the identification of new regulatory strategies to treat asthma according to their phenotypes.
Keywords: Asthma
CD4 T lymphocyte
Refractoriness
Regulatory molecules
keywords: Asma
Linfócito T CD4
Refratariedade
Moléculas reguladoras
Issue Date: 2019
Publisher: Wiley
Citation: FERNANDES, J. S. et al. Impaired immunoregulatory network of the CD4 T lymphocytes in refractory asthma. Clinical and Experimental Allergy, p. 1-11, 2019.
DOI: 10.1111/cea.13351
ISSN: 0954-7894
Copyright: restricted access
Appears in Collections:BA - IGM - Artigos de Periódicos

Files in This Item:
File Description SizeFormat 
Fernandes J.S Impaired immunoregulatory network...2019.pdf509 kBAdobe PDF    Request a copy


FacebookTwitterDeliciousLinkedInGoogle BookmarksBibTex Format mendeley Endnote DiggMySpace

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.