Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/32053
Title: Inhibition of Mayaro virus infection by bovine lactoferrin
Authors: Carvalho, Carlos A. M.
Sousa Junior, Ivanildo P.
Silva, Jerson L.
Oliveira, Andréa C.
Gonçalves, Rafael B.
Gomes, Andre M. O.
Affilliation: Universidade Federal do Rio de Janeiro. Instituto de Bioquímica Médica Leopoldo de Meis. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto de Tecnologia em Imunobiológicos. Rio de Janeiro, RJ, Brasil.
Universidade Federal do Rio de Janeiro. Instituto de Bioquímica Médica Leopoldo de Meis. Rio de Janeiro, RJ, Brasil.
Universidade Federal do Rio de Janeiro. Instituto de Bioquímica Médica Leopoldo de Meis. Rio de Janeiro, RJ, Brasil.
Universidade Federal do Estado do Rio de Janeiro. Departamento de Bioquímica. Instituto Biomédico. Rio de Janeiro, RJ, Brasil.
Universidade Federal do Rio de Janeiro. Instituto de Bioquímica Médica Leopoldo de Meis. Rio de Janeiro, RJ, Brasil.
Abstract: Mayaro virus (MAYV) is an arbovirus linked to several sporadic outbreaks of a highly debilitating febrile illness in many regions of South America. MAYV is on the verge of urbanization from the Amazon region and no effective antiviral intervention is available against human infections. Our aim was to investigate whether bovine lactoferrin (bLf), an iron-binding glycoprotein, could hinder MAYV infection. We show that bLf promotes a strong inhibition of virus infection with no cytotoxic effects. Monitoring the effect of bLf on different stages of infection, we observed that virus entry into the cell is the heavily compromised event. Moreover, we found that binding of bLf to the cell is highly dependent on the sulfation of glycosaminoglycans, suggesting that bLf impairs virus entry by blocking these molecules. Our findings highlight the antiviral potential of bLf and reveal an effective strategy against one of the major emerging human pathogens in the neotropics.
Keywords: Antiviral activity
Bovine lactoferrin
Mayaro virus
Issue Date: 2014
Citation: CARVALHO, Carlos A. M. et al. Inhibition of Mayaro virus infection by bovine lactoferrin. Virology, New York, v. 452-453, p. 297-302, 2014.
DOI: 10.1016/j.virol.2014.01.022
ISSN: 1096-0341
Copyright: open access
Appears in Collections:Biomanguinhos - Artigos de Periódicos

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