Author | Melo, Tatiana Galvão de | |
Author | Meirelles, Maria de Nazareth Silveira Leal de | |
Author | Pereira, Mirian Claudia de Souza | |
Access date | 2019-03-14T14:59:07Z | |
Available date | 2019-03-14T14:59:07Z | |
Document date | 2008 | |
Citation | MELO, Tatiana Galvão de; MEIRELLES, Maria de Nazareth Silveira Leal de; PEREIRA, Mirian Claudia de Souza. Trypanosoma cruzi alters adherens junctions in cardiomyocytes. Microbes and Infection, v. 10, n. 12-13, p. 1405-1410, Oct. 2008. | |
ISSN | 1286-4579 | |
URI | https://www.arca.fiocruz.br/handle/icict/32090 | |
Description | Produção científica do Laboratório de Ultraestrutura Celular. | pt_BR |
Language | eng | en_US |
Publisher | Elsevier | |
Rights | open access | |
Title | Trypanosoma cruzi alters adherens junctions in cardiomyocytes | en_US |
Type | Article | |
DOI | 10.1016/j.micinf.2008.07.044 | |
Abstract | We analyzed the distribution and expression of cadherin and b-catenin during Trypanosoma cruziecardiomyocyte interaction. Confocal microscopy revealed cadherin associated with b-catenin at the cellecell contacts. After 24 h of infection, the spatial distribution and expression of both adherens junction (AJ) proteins remained unaltered. In contrast, loss of N-cadherinecatenin complex was visualized in highly infected cardiomyocytes. Immunoblotting assays corroborated the spatial disorder, showing a 46% reduction in both N-cadherin and b-catenin expression at later infection (72 h of infection). Our data demonstrate that T. cruzi infection disturbs AJs, which can result in loss of cardiac tension and may contribute to the cardiac dysfunctions present in T. cruzi infection. | en_US |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Ultraestrutura Celular. Rio de Janeiro, RJ, Brasil. | |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Ultraestrutura Celular. Rio de Janeiro, RJ, Brasil. | |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Ultraestrutura Celular. Rio de Janeiro, RJ, Brasil. | |
Subject | Trypanosoma cruzi | en_US |
Subject | Cardiomyocytes | en_US |
Subject | Adherens junctions | en_US |
Subject | Cadherin | en_US |
Subject | b-Catenin | en_US |
DeCS | Beta Catenina | pt_BR |
DeCS | Junções Aderentes | pt_BR |
DeCS | Caderinas | pt_BR |
DeCS | Miócitos Cardíacos | pt_BR |
e-ISSN | 1769-714X | |