Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/32186
Title: CD4/CD8 Ratio Predicts Yellow Fever Vaccine-Induced Antibody Titers in Virologically Suppressed HIV-Infected Patients
Authors: Avelino-Silva, Vivian
Miyaj, Karina Takesaki
Mathias, Augusto
Costa, Dayane Alves
Dias, Juliana Zanatta de Carvalho
Lima, Sheila Barbosa
Simoes, Marisol
Freire, Marcos S.
Caiaffa-Filho, Helio H.
Hong, Marisa A.
Lopes, Marta H.
Sartori, Ana M.
Kallas, Esper G.
Affilliation: Faculdade de Medicina da Universidade de São Paulo. Departamento de Doenças Infecciosas e Parasitárias. São Paulo, SP, Brasil.
Faculdade de Medicina da Universidade de São Paulo. Departamento de Doenças Infecciosas e Parasitárias. São Paulo, SP, Brasil.
Faculdade de Medicina da Universidade de São Paulo. Divisão de Clínica de Imunologia e Alergia. São Paulo, SP, Brasil.
Faculdade de Medicina da Universidade de São Paulo. Divisão de Clínica de Imunologia e Alergia. São Paulo, SP, Brasil.
Faculdade de Medicina da Universidade de São Paulo. Divisão de Clínica de Imunologia e Alergia. São Paulo, SP, Brasil.
Fundação Oswaldo Cruz. Instituto de Tecnologia em Imunobiológicos. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto de Tecnologia em Imunobiológicos. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto de Tecnologia em Imunobiológicos. Rio de Janeiro, RJ, Brasil.
Instituto Adolfo Lutz. São Paulo, SP, Brasil.
Instituto Adolfo Lutz. São Paulo, SP, Brasil / Faculdade de Medicina da Universidade de São Paulo. Divisão de Clínica de Imunologia e Alergia. São Paulo, SP, Brasil.
Faculdade de Medicina da Universidade de São Paulo. Departamento de Doenças Infecciosas e Parasitárias. São Paulo, SP, Brasil.
Faculdade de Medicina da Universidade de São Paulo. Departamento de Doenças Infecciosas e Parasitárias. São Paulo, SP, Brasil.
Faculdade de Medicina da Universidade de São Paulo. Departamento de Doenças Infecciosas e Parasitárias. São Paulo, SP, Brasil / Faculdade de Medicina da Universidade de São Paulo. Divisão de Clínica de Imunologia e Alergia. São Paulo, SP, Brasil.
Abstract: BACKGROUND: Yellow fever vaccine (YFV) induces weaker immune responses in HIV-infected individuals. However, little is known about YFV responses among antiretroviral-treated patients and potential immunological predictors of YFV response in this population. METHODS: We enrolled 34 antiretroviral therapy (ART)-treated HIV-infected and 58 HIV-uninfected adults who received a single YFV dose to evaluate antibody levels and predictors of immunity, focusing on CD4(+) T-cell count, CD4(+)/CD8(+) ratio, and Human Pegivirus (GBV-C) viremia. Participants with other immunosuppressive conditions were excluded. RESULTS: Median time since YFV was nonsignificantly shorter in HIV-infected participants than in HIV-uninfected participants (42 and 69 months, respectively, P = 0.16). Mean neutralizing antibody (NAb) titers was lower in HIV-infected participants than HIV-uninfected participants (3.3 vs. 3.6 log10mIU/mL, P = 0.044), a difference that remained significant after adjustment for age, sex, and time since vaccination (P = 0.024). In HIV-infected participants, lower NAb titers were associated with longer time since YFV (rho: -0.38, P = 0.027) and lower CD4(+)/CD8(+) ratio (rho: 0.42, P = 0.014), but not CD4(+) T-cell count (P = 0.52). None of these factors were associated with NAb titers in HIV-uninfected participant. GBV-C viremia was not associated with difference in NAb titers overall or among HIV-infected participants. CONCLUSIONS: ART-treated HIV-infected individuals seem to have impaired and/or less durable responses to YFV than HIV-uninfected individuals, which were associated with lower CD4(+)/CD8(+) ratio, but not with CD4(+) T-cell count. These results supports the notion that low CD4(+)/CD8(+) ratio, a marker linked to persistent immune activation, is a better indicator of functional immune disturbance than CD4(+) T-cell count in patients with successful ART.
Keywords: Yellow fever vaccine
Yellow fever neutralizing antibodies
HIV
CD4+/CD8+ ratio
Immune activation
Issue Date: 2016
Citation: AVELINO-SILVA, Vivian Iida et al. CD4/CD8 Ratio Predicts Yellow Fever Vaccine-Induced Antibody Titers in Virologically Suppressed HIV-Infected Patients. Journal Of Acquired Immune Deficiency Syndromes, Hagerstown, v. 71, n. 2, p.189-195, 2016.
DOI: 10.1097/QAI.0000000000000845
ISSN: 1944-7884
Copyright: open access
Appears in Collections:Biomanguinhos - Artigos de Periódicos

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