| Author | Nicol, A. F. | |
| Author | Nuovo, G. J. | |
| Author | Coelho, J. M. C. | |
| Author | Rolla, V. C. | |
| Author | Horn, C. | |
| Access date | 2019-03-24T16:59:00Z | |
| Available date | 2019-03-24T16:59:00Z | |
| Document date | 2008 | |
| Citation | NICOL, A. F. et al. SOCS in situ expression in tuberculous lymphadenitis in an endemic area. Experimental and Molecular Pathology, v. 84, p. 240–244, 2008. | pt_BR |
| ISSN | 0014-4800 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/32217 | |
| Language | eng | pt_BR |
| Publisher | Elsevier | pt_BR |
| Rights | restricted access | |
| Subject in Portuguese | Tuberculose | pt_BR |
| Subject in Portuguese | Humanos | pt_BR |
| Subject in Portuguese | Linfonodos | pt_BR |
| Subject in Portuguese | Imunofenótipo | pt_BR |
| Subject in Portuguese | Proteínas Supressoras da Sinalização de Citocinas | pt_BR |
| Title | SOCS in situ expression in tuberculous lymphadenitis in an endemic area | pt_BR |
| Type | Article | |
| DOI | 10.1016/j.yexmp.2008.04.001 | |
| Abstract | Background: The immune response to Mycobacterium tuberculosis is complex and multifactorial, the cytokine system being a major factor in M. tuberculosis immunity. Aim: To analyze the immunohistochemical aspects of tuberculous lymph nodes in immunocompetent patients and search for associations between SOCS and cytokine expression in human tuberculous
lymphadenitis. Methods: Thirteen lymph nodes were assayed by immunohistochemistry for SOCS-1 and 3, STAT-3, RANTES, MIP-1-α, ICAM-1, IFN-γ as well as CD45RO, CD20, CD34, CD68, trypsin and lysozyme. Additionally, the RT in situ PCR was performed for SOCS-1 and 3 mRNA detection. Results: Decreased MIP-1α expression together with reduced SOCS-3 (p= 0.042), lysozyme (p= 0.024) and CD45RO (p= 0.05) was observed in the TB lymph nodes compared to the control lymph nodes. In conclusion, the lymphadenitis due to M. tuberculosis was associated with a downregulation of memory T cells (CD45RO), activated lysozymes and SOCS-3 compared to controls, which may play a role in the long-term bacterial replication and altered immune modulation characteristic of the disease. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunopatologia. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | University Hospitals. Department of Pathology. Columbus, OH, USA. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chagas. Laboratório de Patologia. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chagas. Laboratório de Micobactéria. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chagas. Laboratório de Imunologia. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Subject | Tuberculosis | pt_BR |
| Subject | Lymph Nodes | pt_BR |
| Subject | Human | pt_BR |
| Subject | SOCS | pt_BR |
| Subject | Immunophenotype | pt_BR |
| DeCS | Proteínas Supressoras da Sinalização de Citocinas | pt_BR |
| e-ISSN | 1096-0945 | |
| Embargo date | 2028-12-31 | |
