Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/32226
Title: Association study in African-admixed populations across the Americas recapitulates asthma risk loci in non-African populations
Authors: Daya, Michelle
Rafaels, Nicholas
Brunetti, Tonya M
Chavan, Sameer
Levin, Albert M
Shetty, Aniket
Gignoux, Christopher R
Boorgula, Meher Preethi
Wojcik, Genevieve
Campbell, Monica
Vergara, Candelaria
Torgerson, Dara G
Ortega, Victor E
Doumatey, Ayo
Johnston, Henry Richard
Acevedo, Nathalie
Araujo, Maria Ilma
Avila, Pedro C
Belbin, Gillian
Bleecker, Eugene
Bustamante, Carlos
Caraballo, Luis
Cruz, Alvaro
Dunston, Georgia M
Eng, Celeste
Faruque, Mezbah U
Ferguson, Trevor S
Figueiredo, Camila
Ford, Jean G
Gan, Weiniu
Gourraud, Pierre-Antoine
Hansel, Nadia N
Hernandez, Ryan D
Herrera-Paz, Edwin Francisco
Jiménez, Silvia
Kenny, Eimear E
Knight-Madden, Jennifer
Kumar, Rajesh
Lange, Leslie A
Lange, Ethan M
Lizee, Antoine
Maul, Pissamai
Maul, Trevor
Mayorga, Alvaro
Meyers, Deborah
Nicolae, Dan L
O'Connor, Timothy D
Oliveira, Ricardo Riccio
Olopade, Christopher O
Olopade, Olufunmilayo
Qin, Zhaohui S
Rotimi, Charles
Vince, Nicolas
Watson, Harold
Wilks, Rainford J
Wilson, James G
Salzberg, Steven
Ober, Carole
Burchard, Esteban G
Williams, L Keoki
Beaty, Terri H
Taub, Margaret A
Ruczinski, Ingo
Mathias, Rasika A
Barnes, Kathleen C
Affilliation: Múltipla - ver em Notas
Abstract: Asthma is a complex disease with striking disparities across racial and ethnic groups. Despite its relatively high burden, representation of individuals of African ancestry in asthma genome-wide association studies (GWAS) has been inadequate, and true associations in these underrepresented minority groups have been inconclusive. We report the results of a genome-wide meta-analysis from the Consortium on Asthma among African Ancestry Populations (CAAPA; 7009 asthma cases, 7645 controls). We find strong evidence for association at four previously reported asthma loci whose discovery was driven largely by non-African populations, including the chromosome 17q12-q21 locus and the chr12q13 region, a novel (and not previously replicated) asthma locus recently identified by the Trans-National Asthma Genetic Consortium (TAGC). An additional seven loci reported by TAGC show marginal evidence for association in CAAPA. We also identify two novel loci (8p23 and 8q24) that may be specific to asthma risk in African ancestry populations.
Keywords: Asthma
African Continental Ancestry Group
Continental Population Groups
Humans
África
keywords: Asma
Populações de ascendência africana
Grupos raciais
Humanos
África
Issue Date: 2019
Publisher: Nature Research
Citation: DAYA, M. et al. Association study in African-admixed populations across the Americas recapitulates asthma risk loci in non-African populations. Nature Communications, v. 10, p. 880, 2019.
Description: OLIVEIRA, Ricardo Riccio. Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil. Michelle Daya1, Nicholas Rafaels1, Tonya M. Brunetti1, Sameer Chavan1, Albert M. Levin2, Aniket Shetty1, Christopher R. Gignoux1, Meher Preethi Boorgula1, Genevieve Wojcik 3, Monica Campbell1, Candelaria Vergara 4, Dara G. Torgerson5, Victor E. Ortega6, Ayo Doumatey7, Henry Richard Johnston8, Nathalie Acevedo9, Maria Ilma Araujo10, Pedro C. Avila 11, Gillian Belbin12, Eugene Bleecker13, Carlos Bustamante3, Luis Caraballo9, Alvaro Cruz14, Georgia M. Dunston15, Celeste Eng5, Mezbah U. Faruque16, Trevor S. Ferguson 17, Camila Figueiredo18, Jean G. Ford19, Weiniu Gan20, Pierre-Antoine Gourraud21, Nadia N. Hansel4, Ryan D. Hernandez22, Edwin Francisco Herrera-Paz 23,24, Silvia Jiménez9, Eimear E. Kenny12, Jennifer Knight-Madden17, Rajesh Kumar25, Leslie A. Lange1, Ethan M. Lange1, Antoine Lizee21, Pissamai Maul26, Trevor Maul26, Alvaro Mayorga27, Deborah Meyers13, Dan L. Nicolae28, Timothy D. O’Connor29, Ricardo Riccio Oliveira30, Christopher O. Olopade31, Olufunmilayo Olopade28, Zhaohui S. Qin 32, Charles Rotimi 7, Nicolas Vince 21, Harold Watson33, Rainford J. Wilks17, James G. Wilson34, Steven Salzberg 35, Carole Ober36, Esteban G. Burchard22, L. Keoki Williams37, Terri H. Beaty 38, Margaret A. Taub39, Ingo Ruczinski39, CAAPA, Rasika A. Mathias4 & Kathleen C. Barnes1, Ayola Akim Adegnika40, Ganiyu Arinola41, Ulysse Ateba-Ngoa40, Gerardo Ayestas23, Hilda Bjarnadóttir42, Adolfo Correa 43, Said Omar Leiva Erazo23, Marilyn G. Foreman44, Cassandra Foster4, Li Gao4, Jingjing Gao45, Leslie Grammer11, Mark Hansen46, Tina Hartert47, Yijuan Hu32, Iain Königsberg1, Kwang-Youn A. Kim 48, Pamela Landaverde-Torres23, Javier Marrugo49, Beatriz Martinez49, Rosella Martinez23, Luis F. Mayorga23, Delmy-Aracely Mejia-Mejia50, Catherine Meza49, Solomon Musani43, Shaila Musharoff3, Oluwafemi Oluwole28, Maria Pino-Yanes 5, Hector Ramos23, Allan Saenz23, Maureen Samms-Vaughan51, Robert Schleimer11, Alan F. Scott52, Suyash S. Shringarpure3, Wei Song29, Zachary A. Szpiech 22, Raul Torres 53, Gloria Varela23, Olga Marina Vasquez54, Francisco M. De La Vega3, Lorraine B. Ware47 & Maria Yazdanbakhsh 5. 1Department of Medicine, University of Colorado Denver, Aurora, CO 80045, USA. 2Department of Public Health Sciences, Henry Ford Health System, Detroit, MI 48202, USA. 3Department of Genetics, Stanford University School of Medicine, Stanford, CA 94305, USA. 4Department of Medicine, Johns Hopkins University, Baltimore, MD 21224, USA. 5Department of Medicine, University of California San Francisco, San Francisco, CA 94143, USA. 6Center for Human Genomics and Personalized Medicine, Wake Forest School of Medicine, Winston-Salem 27157, USA. 7Center for Research on Genomics & Global Health, National Institutes of Health, Bethesda, MD 20892, USA. 8Department of Human Genetics, Emory University, Atlanta, GA 30322, USA. 9Institute for Immunological Research, Universidad de Cartagena, Cartagena 130000, Colombia 10Immunology Service, Universidade Federal da Bahia, Salvador 401110170, Brazil. 11Department of Medicine, Northwestern University, Chicago, IL 60611, USA. 12Department of Genetics and Genomics, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA. 13Department of Medicine, University of Arizona College of Medicine, Tucson, AZ 85724, USA. 14Universidade Federal da Bahia, Salvador 401110170, Brazil. 15Department of Microbiology, Howard University College of Medicine, Washington, DC 20059, USA. 16National Human Genome Center, Howard University College of Medicine, Washington, DC 20059, USA. 17Caribbean Institute for Health Research, The University of the West Indies, Kingston 00007, Jamaica. 18Departamento de Biorregulacao, Universidade Federal da Bahia, Salvador 401110170, Brazil. 19Department of Medicine, Einstein Medical Center, Philadelphia, PA 19141, USA. 20National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA. 21Université de Nantes, INSERM, Centre de Recherche en Transplantation et Immunologie, UMR, 1064ATIP-Avenir, Equipe 5, Nantes, France. 22Department of Bioengineering and Therapeutic Sciences, University of California San Francisco, San Francisco, CA 94143, USA. 23Facultad de Medicina, Universidad Católica de Honduras, San Pedro Sula 21102, Honduras. 24Universidad Tecnológica Centroamericana (UNITEC), Facultad de Ciencias Médicas, Tegucigalpa, Honduras. 25Department of Pediatrics, Northwestern University, Chicago, IL 60611, USA. 26Genetics and Epidemiology of Asthma in Barbados, The University of the West Indies, Chronic Disease Research Centre, Jemmots Lane, St. Michael BB11115, Barbados. 27Centro de Neumologia y Alergias, San Pedro Sula 21102, Honduras. 28Department of Medicine, University of Chicago, Chicago, IL 60637, USA. 29Institute for Genome Sciences, University of Maryland School of Medicine, Baltimore, MD 21201, USA. 30Laboratório de Patologia Experimental, Centro de Pesquisas Gonçalo Moniz, Salvador 40296-710, Brazil. 31Department of Medicine and Center for Global Health, University of Chicago, Chicago, IL 60637, USA. 32Department of Biostatistics and Bioinformatics, Emory University, Atlanta, GA 30322, USA. 33Faculty of Medical Sciences, The University of the West Indies, Queen Elizabeth Hospital, Bridgetown, St. Michael BB11000, Barbados. 34Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, MS 39216, USA. 35Departments of Biomedical Engineering and Biostatistics, Johns Hopkins University, Baltimore, MD 21205, USA. 36Department of Human Genetics, University of Chicago, Chicago, IL 60637, USA. 37Center for Individualized and Genomic Medicine Research, Henry Ford Health System, Detroit, MI 48202, USA. 38Department of Epidemiology, Bloomberg School of Public Health, JHU, Baltimore, MD 21205, USA. 39Department of Biostatistics, Bloomberg School of Public Health, JHU, Baltimore, MD 21205, USA. These authors contributed equally: Rasika A. Mathias, Kathleen C. Barnes.40Centre de Recherches Médicales de Lambaréné, BP:242, Lambaréné 13901, Gabon. 41Department of Chemical Pathology, University of Ibadan, Ibadan 900001, Nigeria. 42Faculty of Medicine, University of Iceland, 101 Reykjavík, Iceland. 43Department of Medicine, University of Mississippi Medical Center, Jackson, MS 39216, USA. 44Pulmonary and Critical Care Medicine, Morehouse School of Medicine, Atlanta, GA 30310, USA. 45Data and Statistical Sciences, AbbVie, North Chicago, IL 60064, USA. 46Illumina, Inc., San Diego, CA 92122, USA. 47Department of Medicine, Vanderbilt University, Nashville, TN 37232, USA. 48Department of Preventive Medicine, Northwestern University, Chicago, IL 60611, USA. 49Instituto de Investigaciones Immunologicas, Universidad de Cartagena, Cartagena 130000, Colombia. 50Facultad de Ciencias de la Salud, Universidad Tecnológica Centroamericana (UNITEC), San Pedro Sula 21102, Honduras. 51Department of Child Health, The University of the West Indies, Kingston 00007, Jamaica. 52Department of Medicine, Johns Hopkins University, Baltimore, MD 21287, USA. 53Biomedical Sciences Graduate Program, University of California San Francisco, San Francisco, CA 94158, USA. 54Centro Medico de la Familia, San Pedro Sula 21102, Honduras. 55Department of Parasitology, Leiden University Medical Center, Leiden 02333, Netherlands
DOI: 10.1038/s41467-019-08469-7
ISSN: 2041-1723
Copyright: open access
Appears in Collections:BA - IGM - Artigos de Periódicos

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