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AutorEspíndola, Otávio M.
AutorOliveira, Luã C.
AutorFerreira, Priscilla M. S.
AutorLeite, Ana Claudia C. B.
AutorLima, Marco Antonio S. D.
AutorAndrada-Serpa, Maria José
Fecha de acceso2019-03-27T13:47:40Z
Fecha de disponibilización2019-03-27T13:47:40Z
Fecha de publicación2015
ReferenciaESPÍNDOLA, Otávio M. et al. High IFN-γ/IL-10 expression ratio and increased frequency of persistent human T-cell lymphotropic virus Type 1-infected clones are associated with human T-cell lymphotropic virus type 1-associated myelopathy/tropical spastic paraparesis development. Intervirology, v. 58, n. 2, p. 106-114, 2015.pt_BR
ISSN0300-5526pt_BR
URIhttps://www.arca.fiocruz.br/handle/icict/32245
Idiomaengpt_BR
EditorKarger Publisherspt_BR
Derechos de autoropen accesspt_BR
TítuloHigh IFN-γ/IL-10 expression ratio and increased frequency of persistent human T-cell lymphotropic virus type 1-infected clones are associated with human T-cell lymphotropic virus type 1-associated myelopathy/tropical spastic paraparesis developmentpt_BR
Tipo del documentoArticlept_BR
DOI10.1159/000371766
Resumen en InglésHuman T-cell lymphotropic virus type 1 (HTLV-1) is a retrovirus that causes a persistent infection, and only 0.5-5% of infected individuals will develop HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). Therefore, we investigated parameters to discriminate HTLV-1 asymptomatic carriers (ACs) with an increased chance to develop HAM/TSP. Methods: We evaluated integration patterns of HTLV-1 provirus, the relative expression of HTLV-1 tax and HBZ mRNAs and of IFN-γ and IL-10 mRNAs, in addition to proviral load (PVL) levels. Results: HAM/TSP patients presented a higher number of large persistent HTLV-1-carrying clones compared to ACs, and the expression of the HTLV-1 tax and HBZ genes by infected cells was detected at low levels and correlated positively with PVL. In addition, HAM/TSP patients and ACs with high PVL expressed higher levels of IFN-γ mRNA in comparison to IL-10, while ACs with low PVL presented an equilibrate IFN-γ/IL-10 ratio. Conclusions: The presence of large persistent HTLV1-infected clones in association with viral gene expression, even at small levels, could stimulate the intense inflammatory response in HTLV-1-infected individuals. This was supported by a high ratio of IFN-γ/IL-10 relative expression in HAM/TSP patients and ACs with high PVL, indicating that these parameters could aid the identification of ACs with a high risk to develop HAM/TSP.pt_BR
AfiliaciónFundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa em Patogenia Viral. Rio de Janeiro, RJ, Brasil.pt_BR
AfiliaciónFundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa em Patogenia Viral. Rio de Janeiro, RJ, Brasil.pt_BR
AfiliaciónFundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa em Patogenia Viral. Rio de Janeiro, RJ, Brasil.pt_BR
AfiliaciónFundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em Neuroinfecções. Rio de Janeiro, RJ, Brasil.pt_BR
AfiliaciónFundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em Neuroinfecções. Rio de Janeiro, RJ, Brasil / The Federal University of Rio de Janeiro. Neurology Department. Rio de Janeiro, RJ, Brasil.pt_BR
AfiliaciónFundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa em Patogenia Viral. Rio de Janeiro, RJ, Brasil.pt_BR
Palavras clave en InglêsHuman T-cell lymphotropic virus type 1pt_BR
Palavras clave en InglêsHuman T-cell lymphotropic virus type 1-associated myelopathy/tropical spastic paraparesispt_BR
Palavras clave en InglêsIFN-γpt_BR
Palavras clave en InglêsIL-10pt_BR
Palavras clave en InglêsClonalitypt_BR
Palavras clave en InglêsBiological markerspt_BR
e-ISSN1423-0100
Fecha de embargo2020-03-28


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