Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/32301
Title: Liver ultrasound elastography for the evaluation of periportal fibrosis in schistosomiasis mansoni: a cross-sectional study
Authors: Santos, Joelma Carvalho
Batista, Andrea Dória
Vasconcelos, Carla Maria Mola
Lemos, Roberto Souza
Souza Junior, Valter Romão de
Dessein, Alain
Dessein, Hélia
Montenegro, Silvia Maria Lucena
Lopes, Edmundo Pessoa Almeida
Domingues, Ana Lúcia Coutinho
Affilliation: Universidade Federal de Pernambuco. Centro de Ciências da Saúde. Recife, PE, Brasil.
Universidade Federal de Pernambuco. Hospital das Clínicas. Recife, PE, Brasil.
Universidade Federal de Pernambuco. Recife, PE, Brasil.
Universidade Federal de Pernambuco. Centro de Ciências da Saúde. Recife, PE, Brasil.
Universidade Federal de Pernambuco. Recife, PE, Brasil.
Faculté de Médecine. Aix-Marseille Université. Marseille, France.
Faculté de Médecine. Aix-Marseille Université. Marseille, France.
Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Departamento de Imunologia. Recife, PE, Brasil.
Universidade Federal de Pernambuco. Centro de Ciências da Saúde. Recife, PE, Brasil / Universidade Federal de Pernambuco. Hospital das Clínicas. Recife, PE, Brasil.
Universidade Federal de Pernambuco. Centro de Ciências da Saúde. Recife, PE, Brasil / Universidade Federal de Pernambuco. Hospital das Clínicas. Recife, PE, Brasil.
Abstract: ARFI elastrography has been used as a noninvasive method to assess the severity of liver fibrosis in viral hepatitis, although with few studies in schistosomiasis mansoni. We aimed to evaluate the performance of point shear wave elastography (pSWE) for predicting significant periportal fibrosis (PPF) in schistosomotic patients and to determine its best cutoff point. Methodology/principal findings This cross-sectional study included 358 adult schistosomotic patients subjected to US and pSWE on the right lobe. Two hundred two patients (62.0%) were women, with a median age of 54 (ranging 18–92) years. The pSWE measurements were compared to the US patterns of PPF, as gold standard, according to the Niamey classification. The performance of pSWE was calculated as the area under the ROC curve (AUC). Patients were further classified into two groups: 86 patients with mild PPF and 272 patients with significant PPF. The median pSWE of the significant fibrosis group was higher (1.40 m/s) than that of mild fibrosis group (1.14 m/s, p<0.001). AUC was 0.719 with ≤1.11 m/s as the best cutoff value for excluding significant PPF. Sensitivity and negative predictive values were 80.5% and 40.5%, respectively. Whereas, for confirming significant PPF, the best cutoff value was >1.39 m/s, with specificity of 86.1% and positive predictive value of 92.0%. Conclusions/significance pSWE was able to differentiate significant from mild PPF, with better performance to predict significant PPF.
Keywords: Ultrasound elastography
Periportal fibrosis
Schistosomiasis mansoni
DeCS: Adolescente
Adulto
Envelhecido
Idoso, 80 anos ou mais
Técnicas de Imagem de Elasticidade / métodos
Fêmea
Humanos
Fígado / diagnóstico por imagem
Cirrose Hepática / diagnóstico
Cirrose Hepática / diagnóstico por imagem
Masculino
Meia idade
Esquistossomose mansônica / diagnóstico
Esquistossomose mansoni / diagnóstico por imagem
Sensibilidade e Especificidade
Ultrassonografia / métodos
Adulto jovem
Issue Date: 2018
Citation: SANTOS, Joelma Carvalho et al. Liver ultrasound elastography for the evaluation of periportal fibrosis in schistosomiasis mansoni: a cross-sectional study. PLoS Neglected Tropical Diseases, v. 12, n. 11, p. 1-9, Nov. 2018.
DOI: 10.1371/journal.pntd.0006868
ISSN: 1935-2735
Copyright: open access
Appears in Collections:PE - IAM - Artigos de Periódicos




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