| Author | Araujo-Jorge, Tania Cremonini de | |
| Author | Waghabi, Mariana Caldas | |
| Author | Soeiro, Maria de Nazaré Correia | |
| Author | Keramidas, Michelle | |
| Author | Bailly, Sabine | |
| Author | Feige, Jean-Jacques | |
| Access date | 2019-04-02T16:58:21Z | |
| Available date | 2019-04-02T16:58:21Z | |
| Document date | 2008 | |
| Citation | ARAUJO-JORGE, Tania Cremonini de et al. Pivotal role for TGF-β in infectious heart disease: the case of Trypanosoma cruzi infection and consequent Chagasic myocardiopathy. Cytokine & Growth Factor Reviews, v. 19, n. 5-6, p. 405-413, Oct./Dec. 2008. | |
| ISSN | 1359-6101 | |
| URI | https://www.arca.fiocruz.br/handle/icict/32333 | |
| Description | Produção científica do Laboratório de Biologia Celular. | pt_BR |
| Description | Produção científica do Laboratório de Genômica Funcional e Bioinformática (vigente até jan/2023). | pt_BR |
| Language | eng | en_US |
| Publisher | Elsevier | |
| Rights | restricted access | |
| Subject in Portuguese | Doença de Chagas | pt_BR |
| Subject in Portuguese | Trypanosoma cruzi | pt_BR |
| Subject in Portuguese | TGF-β | pt_BR |
| Subject in Portuguese | Fibrose cardíaca | pt_BR |
| Title | Pivotal role for TGF-β in infectious heart disease: the case of Trypanosoma cruzi infection and consequent Chagasic myocardiopathy | en_US |
| Type | Article | |
| DOI | 10.1016/j.cytogfr.2008.08.002 | |
| Abstract | This paper summarizes recent data from the literature suggesting that transforming growth factor-β (TGF-β) participates at least in four different processes influencing development of myocardiopathy in Chagas disease, a major parasitic illness caused by Trypanosoma cruzi infection: (a) invasion of cardiac fibroblasts and myocytes; (b) intracellular parasite cycle; (c) regulation of inflammation and immune response; (d) fibrosis and heart remodeling during acute and chronic disease. All these effects point to an important role of TGF-β in Chagas disease myocardiopathy and suggest that monitoring the circulating levels of this cytokine could be of help in clinical prognosis and management of patients. Moreover, TGF-β-interfering therapies appear as interesting adjuvant interventions during acute and chronic phases of T. cruzi infection. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Celular. Rio de Janeiro, RJ, Brasil. | |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Celular. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Genômica Funcional e Bioinformática. Rio de Janeiro, RJ, Brasil. | |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Celular. Rio de Janeiro, RJ, Brasil. | |
| Affilliation | Institut National de la Santé et de la Recherche Médicale. Unité 878. Grenoble, France / Institut de Recherches en Technologies et Sciences pour le Vivant. Commissariat à L'Energie Atomique. Grenoble, France / Université Joseph Fourier. Grenoble, France. | |
| Affilliation | Institut National de la Santé et de la Recherche Médicale. Unité 878. Grenoble, France / Institut de Recherches en Technologies et Sciences pour le Vivant. Commissariat à L'Energie Atomique. Grenoble, France / Université Joseph Fourier. Grenoble, France. | |
| Affilliation | Institut National de la Santé et de la Recherche Médicale. Unité 878. Grenoble, France / Institut de Recherches en Technologies et Sciences pour le Vivant. Commissariat à L'Energie Atomique. Grenoble, France / Université Joseph Fourier. Grenoble, France. | |
| Subject | TGF-β | en_US |
| Subject | Chagas Disease | en_US |
| Subject | Trypanosoma cruzi | en_US |
| Subject | Cardiac fibrosis | en_US |
| e-ISSN | 1879-0305 | |
| xmlui.metadata.dc.subject.ods | 03 Saúde e Bem-Estar | |
