Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/32333

Type
Article
Copyright
Restricted access
Sustainable Development Goals
03 Saúde e Bem-Estar
Collections
Share

Statistics
Metadata
Show full item record

PIVOTAL ROLE FOR TGF-β IN INFECTIOUS HEART DISEASE: THE CASE OF TRYPANOSOMA CRUZI INFECTION AND CONSEQUENT CHAGASIC MYOCARDIOPATHY
Araujo-Jorge, Tania Cremonini de et al. | Date Issued: 2008
Author
Araujo-Jorge, Tania Cremonini de
Waghabi, Mariana Caldas
Soeiro, Maria de Nazaré Correia
Keramidas, Michelle
Bailly, Sabine
Feige, Jean-Jacques
Affilliation
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Celular. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Celular. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Genômica Funcional e Bioinformática. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Celular. Rio de Janeiro, RJ, Brasil.
Institut National de la Santé et de la Recherche Médicale. Unité 878. Grenoble, France / Institut de Recherches en Technologies et Sciences pour le Vivant. Commissariat à L'Energie Atomique. Grenoble, France / Université Joseph Fourier. Grenoble, France.
Institut National de la Santé et de la Recherche Médicale. Unité 878. Grenoble, France / Institut de Recherches en Technologies et Sciences pour le Vivant. Commissariat à L'Energie Atomique. Grenoble, France / Université Joseph Fourier. Grenoble, France.
Institut National de la Santé et de la Recherche Médicale. Unité 878. Grenoble, France / Institut de Recherches en Technologies et Sciences pour le Vivant. Commissariat à L'Energie Atomique. Grenoble, France / Université Joseph Fourier. Grenoble, France.
Abstract
This paper summarizes recent data from the literature suggesting that transforming growth factor-β (TGF-β) participates at least in four different processes influencing development of myocardiopathy in Chagas disease, a major parasitic illness caused by Trypanosoma cruzi infection: (a) invasion of cardiac fibroblasts and myocytes; (b) intracellular parasite cycle; (c) regulation of inflammation and immune response; (d) fibrosis and heart remodeling during acute and chronic disease. All these effects point to an important role of TGF-β in Chagas disease myocardiopathy and suggest that monitoring the circulating levels of this cytokine could be of help in clinical prognosis and management of patients. Moreover, TGF-β-interfering therapies appear as interesting adjuvant interventions during acute and chronic phases of T. cruzi infection.
Keywords in Portuguese
Doença de Chagas
Trypanosoma cruzi
TGF-β
Fibrose cardíaca
 
Keywords
TGF-β
Chagas Disease
Trypanosoma cruzi
Cardiac fibrosis
 
Publisher
Elsevier
Citation
ARAUJO-JORGE, Tania Cremonini de et al. Pivotal role for TGF-β in infectious heart disease: the case of Trypanosoma cruzi infection and consequent Chagasic myocardiopathy. Cytokine & Growth Factor Reviews, v. 19, n. 5-6, p. 405-413, Oct./Dec. 2008.
DOI
10.1016/j.cytogfr.2008.08.002
ISSN
1359-6101
Notes
Produção científica do Laboratório de Biologia Celular.
Produção científica do Laboratório de Genômica Funcional e Bioinformática (vigente até jan/2023).