Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/32333
Title: Pivotal role for TGF-beta in infectious heart disease: The case of Trypanosoma cruzi infection and consequent Chagasic myocardiopathy
Authors: Araújo-Jorge, Tania C.
Waghabi, Mariana C.
Soeiro, Maria de Nazaré C.
Keramidas, Michelle
Bailly, Sabine
Feige, Jean-Jacques
Affilliation: Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Celular. Rio de Janeiro, RJ. Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Celular. Rio de Janeiro, RJ. Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Genômica Funcional e Bioinformática. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Celular. Rio de Janeiro, RJ. Brasil.
Institut National de la Santé et de la Recherche Médicale. Unité 878. Grenoble, France / Commissariat à L`Energie Atomique, Institut de Recherches en Technologies et Sciences pour le Vivant. Grenoble, France / Université Joseph Fourier. Grenoble, France.
Institut National de la Santé et de la Recherche Médicale. Unité 878. Grenoble, France / Commissariat à L`Energie Atomique, Institut de Recherches en Technologies et Sciences pour le Vivant. Grenoble, France / Université Joseph Fourier. Grenoble, France.
Institut National de la Santé et de la Recherche Médicale. Unité 878. Grenoble, France / Commissariat à L`Energie Atomique, Institut de Recherches en Technologies et Sciences pour le Vivant. Grenoble, France / Université Joseph Fourier. Grenoble, France.
Abstract: This paper summarizes recent data from the literature suggesting that transforming growth factor-beta (TGF-beta) participates at least in four different processes influencing development of myocardiopathy in Chagas disease, a major parasitic illness caused by Trypanosoma cruzi infection: (a) invasion of cardiac fibroblasts and myocytes; (b) intracellular parasite cycle; (c) regulation of inflammation and immune response; (d) fibrosis and heart remodeling during acute and chronic disease. All these effects point to an important role of TGF-beta in Chagas disease myocardiopathy and suggest that monitoring the circulating levels of this cytokine could be of help in clinical prognosis and management of patients. Moreover, TGF-beta-interfering therapies appear as interesting adjuvant interventions during acute and chronic phases of T. cruzi infection.
Keywords: TGF-b
Chagas Disease
Trypanosoma cruzi
Cardiac fibrosis
keywords: Doença de Chagas
Trypanosoma cruzi
TGF-b
Fibrose cardíaca
Issue Date: 2008
Publisher: Elsevier
Citation: ARAUJO-JORGE, Tania C. et al. Pivotal role for TGF-b in infectious heart disease: The case of Trypanosoma cruzi infection and consequent Chagasic myocardiopathy. Cytokine & Growth Factor Reviews, v. 19, p. 405-413, Oct. 2008.
DOI: 10.1016/j.cytogfr.2008.08.002
ISSN: 1359-6101
Copyright: restricted access
Appears in Collections:IOC - Artigos de Periódicos

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