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PIVOTAL ROLE FOR TGF-BETA IN INFECTIOUS HEART DISEASE: THE CASE OF TRYPANOSOMA CRUZI INFECTION AND CONSEQUENT CHAGASIC MYOCARDIOPATHY
Araujo-Jorge, Tania C. et al. | Date Issued: 2008
Author
Araujo-Jorge, Tania C.
Waghabi, Mariana C.
Soeiro, Maria de Nazaré C.
Keramidas, Michelle
Bailly, Sabine
Feige, Jean-Jacques
Affilliation
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Celular. Rio de Janeiro, RJ. Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Celular. Rio de Janeiro, RJ. Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Genômica Funcional e Bioinformática. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Celular. Rio de Janeiro, RJ. Brasil.
Institut National de la Santé et de la Recherche Médicale. Unité 878. Grenoble, France / Commissariat à L`Energie Atomique, Institut de Recherches en Technologies et Sciences pour le Vivant. Grenoble, France / Université Joseph Fourier. Grenoble, France.
Institut National de la Santé et de la Recherche Médicale. Unité 878. Grenoble, France / Commissariat à L`Energie Atomique, Institut de Recherches en Technologies et Sciences pour le Vivant. Grenoble, France / Université Joseph Fourier. Grenoble, France.
Institut National de la Santé et de la Recherche Médicale. Unité 878. Grenoble, France / Commissariat à L`Energie Atomique, Institut de Recherches en Technologies et Sciences pour le Vivant. Grenoble, France / Université Joseph Fourier. Grenoble, France.
Abstract
This paper summarizes recent data from the literature suggesting that transforming growth factor-beta (TGF-beta) participates at least in four different processes influencing development of myocardiopathy in Chagas disease, a major parasitic illness caused by Trypanosoma cruzi infection: (a) invasion of cardiac fibroblasts and myocytes; (b) intracellular parasite cycle; (c) regulation of inflammation and immune response; (d) fibrosis and heart remodeling during acute and chronic disease. All these effects point to an important role of TGF-beta in Chagas disease myocardiopathy and suggest that monitoring the circulating levels of this cytokine could be of help in clinical prognosis and management of patients. Moreover, TGF-beta-interfering therapies appear as interesting adjuvant interventions during acute and chronic phases of T. cruzi infection.
Keywords in Portuguese
Doença de Chagas
Trypanosoma cruzi
TGF-b
Fibrose cardíaca
 
Keywords
TGF-b
Chagas Disease
Trypanosoma cruzi
Cardiac fibrosis
 
Publisher
Elsevier
Citation
ARAUJO-JORGE, Tania C. et al. Pivotal role for TGF-b in infectious heart disease: The case of Trypanosoma cruzi infection and consequent Chagasic myocardiopathy. Cytokine & Growth Factor Reviews, v. 19, p. 405-413, Oct. 2008.
DOI
10.1016/j.cytogfr.2008.08.002
ISSN
1359-6101