Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/32414
Title: Studies on yellow fever vaccine II: stability of the reconstituted product
Authors: Lopes, Oscar de Souza
Guimarães, Suely S. D. de Almeida
Carvalho, Ricardo de Carvalho
Affilliation: Fundação Oswaldo Cruz. Instituto de Tecnologia em Imunobiológicos. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto de Tecnologia em Imunobiológicos. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto de Tecnologia em Imunobiológicos. Rio de Janeiro, RJ, Brasil.
Abstract: This work evaluated the stability of diluted yellow fever vaccine in order to determine conditions that maintain the minimum of 3 log10 of 17D virus per human dose as required by WHO. The vaccines were held at 0 °C or at 37 °C and were diluted either with distilled water, with 0·15 m saline or with 0·15 m PBS at pH 5·5, 7·2 and 8·0. In a next step, stabilizer substances such as gelatin and peptone were added to the vaccines. Dilution of the vaccines in distilled water maintained the virus titre for up to three hours at 37 °C and this diluent has been adopted for routine use in Brazil.
Keywords: Studies
Yellow fever vaccine
Issue Date: 1988
Citation: LOPES, Oscar de Souza; GUIMARÃES, Suely S. D. de Almeida; CARVALHO, Ricardo de. Studies on yellow fever vaccine II: stability of the reconstituted product. Journal of Biological Standardization, London, v. 16, n. 2, p. 71-76, 1988.
DOI: 10.1016/0092-1157(88)90033-9
ISSN: 0092-1157
Copyright: restricted access
Appears in Collections:Biomanguinhos - Artigos de Periódicos

Files in This Item:
File Description SizeFormat 
1-s2.0-0092115788900339-main.pdf291.3 kBAdobe PDF    Request a copy



FacebookTwitterDeliciousLinkedInGoogle BookmarksBibTex Format mendeley Endnote DiggMySpace

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.