| Author | Justino, Maria Cleonice A. | |
| Author | Brasil, Patrícia | |
| Author | Abreu, Erika | |
| Author | Miranda, Yllen | |
| Author | Mascarenhas, Joana D'Arc P. | |
| Author | Guerra, Sylvia F. S. | |
| Author | Linhares, Alexandre C. | |
| Access date | 2019-04-15T14:07:05Z | |
| Available date | 2019-04-15T14:07:05Z | |
| Document date | 2016 | |
| Citation | JUSTINO, Maria Cleonice A. et al. Clinical severity and rotavirus vaccination among children hospitalized for acute gastroenteritis in Belém, Northern Brazil. Journal of Tropical Pediatrics, v. 62, p. 276-281, Feb. 2016. | pt_BR |
| ISSN | 0142-6338 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/32486 | |
| Language | eng | pt_BR |
| Publisher | Oxford University Press | pt_BR |
| Rights | open access | pt_BR |
| Title | Clinical severity and rotavirus vaccination among children hospitalized for acute gastroenteritis in Belém, Northern Brazil | pt_BR |
| Type | Article | pt_BR |
| DOI | 10.1093/tropej/fmv098 | |
| Abstract | In March 2006, Brazil introduced the monovalent rotavirus (RV) vaccine (Rotarix™) into the public sector. This study assessed the severity of rotavirus gastroenteritis (RVGE) according to the vaccination status among hospitalized children. We identified 1023 RVGE episodes among not vaccinated (n = 252), partially vaccinated (n = 156) and fully vaccinated (n = 615) children. Very severe gastroenteritis (scored ≥ 15) was reported in 16.7, 17.9 and 13.5% of not vaccinated, partially vaccinated and fully vaccinated children, respectively. There was a trend for a shorter duration of RV diarrhoea among vaccinated children than in not vaccinated children (p = 0.07). A protective effect of vaccination was noted when mean duration of symptoms and hospital stay are analysed, comparing unvaccinated, partially vaccinated and fully vaccinated children (p < 0.05). We showed a vaccination dose effect trend, with fully vaccinated children having less-severe RVGE than not vaccinated and partially vaccinated children. | pt_BR |
| Affilliation | Ministério da Saúde. Secretaria de Vigilância em Saúde. Instituto Evandro Chagas. Ananindeua, PA, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chagas. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Ministério da Saúde. Secretaria de Vigilância em Saúde. Instituto Evandro Chagas. Ananindeua, PA, Brasil. | pt_BR |
| Affilliation | Ministério da Saúde. Secretaria de Vigilância em Saúde. Instituto Evandro Chagas. Ananindeua, PA, Brasil. | pt_BR |
| Affilliation | Ministério da Saúde. Secretaria de Vigilância em Saúde. Instituto Evandro Chagas. Ananindeua, PA, Brasil. | pt_BR |
| Affilliation | Ministério da Saúde. Secretaria de Vigilância em Saúde. Instituto Evandro Chagas. Ananindeua, PA, Brasil. | pt_BR |
| Affilliation | Ministério da Saúde. Secretaria de Vigilância em Saúde. Instituto Evandro Chagas. Ananindeua, PA, Brasil. | pt_BR |
| Subject | Rotavirus | pt_BR |
| Subject | Gastroenteritis | pt_BR |
| Subject | Severity | pt_BR |
| Subject | Vaccination status | pt_BR |
| e-ISSN | 10.1093/tropej/fmv098 | |
| Embargo date | 2020-04-15 | |
