Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/32486
Title: Clinical severity and rotavirus vaccination among children hospitalized for acute gastroenteritis in Belém, Northern Brazil
Authors: Justino, Maria Cleonice A.
Brasil, Patrícia
Abreu, Erika
Miranda, Yllen
Mascarenhas, Joana D'Arc P.
Guerra, Sylvia F. S.
Linhares, Alexandre C.
Affilliation: Ministério da Saúde. Secretaria de Vigilância em Saúde. Instituto Evandro Chagas. Ananindeua, PA, Brasil.
Fundação Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chagas. Rio de Janeiro, RJ, Brasil.
Ministério da Saúde. Secretaria de Vigilância em Saúde. Instituto Evandro Chagas. Ananindeua, PA, Brasil.
Ministério da Saúde. Secretaria de Vigilância em Saúde. Instituto Evandro Chagas. Ananindeua, PA, Brasil.
Ministério da Saúde. Secretaria de Vigilância em Saúde. Instituto Evandro Chagas. Ananindeua, PA, Brasil.
Ministério da Saúde. Secretaria de Vigilância em Saúde. Instituto Evandro Chagas. Ananindeua, PA, Brasil.
Ministério da Saúde. Secretaria de Vigilância em Saúde. Instituto Evandro Chagas. Ananindeua, PA, Brasil.
Abstract: In March 2006, Brazil introduced the monovalent rotavirus (RV) vaccine (Rotarix™) into the public sector. This study assessed the severity of rotavirus gastroenteritis (RVGE) according to the vaccination status among hospitalized children. We identified 1023 RVGE episodes among not vaccinated (n = 252), partially vaccinated (n = 156) and fully vaccinated (n = 615) children. Very severe gastroenteritis (scored ≥ 15) was reported in 16.7, 17.9 and 13.5% of not vaccinated, partially vaccinated and fully vaccinated children, respectively. There was a trend for a shorter duration of RV diarrhoea among vaccinated children than in not vaccinated children (p = 0.07). A protective effect of vaccination was noted when mean duration of symptoms and hospital stay are analysed, comparing unvaccinated, partially vaccinated and fully vaccinated children (p < 0.05). We showed a vaccination dose effect trend, with fully vaccinated children having less-severe RVGE than not vaccinated and partially vaccinated children.
Keywords: Rotavirus
Gastroenteritis
Severity
Vaccination status
Issue Date: 2016
Publisher: Oxford University Press
Citation: JUSTINO, Maria Cleonice A. et al. Clinical severity and rotavirus vaccination among children hospitalized for acute gastroenteritis in Belém, Northern Brazil. Journal of Tropical Pediatrics, v. 62, p. 276-281, Feb. 2016.
DOI: 10.1093/tropej/fmv098
ISSN: 0142-6338
Copyright: restricted access
Appears in Collections:INI - Artigos de Periódicos

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