Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/32507
Title: Leishmania lysosomal targeting signal is recognized by yeast and not by mammalian cells
Authors: Marín-Villa, Marcel
Morgado, Graziela Sampaio
Roy, Deepanita
Traub-Cseko, Yara M.
Affilliation: Universidad de Antioquia. Facultad de Medicina. Programa de Estudio y Control de Enfermedades Tropicales. Medellin, Colombia.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Molecular de Tripanosomatídeos. Rio de Janeiro, RJ. Brasil.
Yale University School of Medicine. Section of Microbial Pathogenisis. New Haven, CT, USA.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Molecular de Tripanosomatídeos. Rio de Janeiro, RJ. Brasil.
Abstract: Leishmaniasis, caused by Leishmania parasites, is an important public health problem worldwide. Leishmania, like other trypanosomatids, present unique biological features as compared to higher eukaryotes that can be exploited with the intent of finding new chemotherapeutical/vaccine candidates. Mechanisms of cellular sorting in Leishmania can be viewed as such potential targets. We have previously demonstrated a role for the pro-domain of a Leishmania cysteine proteinase in lysosomal targeting. In this paper, we show that this signal is not recognized by mammalian cells and is recognized by yeast; we also discuss here the implications of these findings related to evolution and further characterization of the Leishmania trafficking machinery.
Keywords: Lieshmania
Lysosomal targeting
Yeast
Mammalian cells
keywords: Leishmania
Direcionamento lisossômico
Levedura
Células de mamíferos
Issue Date: 2008
Publisher: Springer Verlag
Citation: MARIN-VILLA, Marcel et al. Leishmania lysosomal targeting signal is recognized by yeast and not by mammalian cells. Parasitol Res., v. 103, p. 983-988, 2008.
DOI: 10.1007/s00436-008-1047-8
ISSN: 0932-0113
Copyright: restricted access
Appears in Collections:IOC - Artigos de Periódicos

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