| Author | Beck, Lílian | |
| Author | Van-Lüme, Danielle S. M. | |
| Author | Souza, Joelma R. | |
| Author | Domingues, Ana L. C. | |
| Author | Favre, Tereza | |
| Author | Abath, Frederico Guilherme Coutinho | |
| Author | Montenegro, Silvia L. M. | |
| Access date | 2019-04-16T15:34:19Z | |
| Available date | 2019-04-16T15:34:19Z | |
| Document date | 2008 | |
| Citation | BECK, Lilian et al. Discriminating acute from chronic human schistosomiasis mansoni. Acta Tropica, v. 108, p. 229–233, 2008. | pt_BR |
| ISSN | 0001-706X | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/32521 | |
| Language | eng | pt_BR |
| Publisher | Elsevier | pt_BR |
| Rights | restricted access | |
| Subject in Portuguese | Diagnóstico Diferencial | pt_BR |
| Subject in Portuguese | Schistosoma mansoni | pt_BR |
| Subject in Portuguese | Características operacionais do receptor | pt_BR |
| Subject in Portuguese | Esquistossomose aguda | pt_BR |
| Subject in Portuguese | Esquistossomose crônica | pt_BR |
| Title | Discriminating acute from chronic human schistosomiasis mansoni | pt_BR |
| Type | Article | |
| DOI | 10.1016/j.actatropica.2008.08.012 | |
| Abstract | Specific immunoglobulin (IgA, IgG and IgM) responses to different antigen targets (soluble eggs antigen
– SEA, soluble worm adult protein – SWAP and keyhole limpet hole – KLH) were measured by enzyme
linked immunosorbent assay (ELISA) in patients with acute and chronic schistosomiasis, aswell as patients
without schistosomiasis. SEA IgA and KLH IgM presented high discriminatory powers to distinguish acute
from chronic schistosomiasis, with calculated areas under the curve (AUCs) of 0.88 and 0.82, respectively,
obtained from receiver operating characteristic (ROC) curve. On the other hand, these tests, particularly
SEA IgA were not useful to distinguish schistosomiasis (including the acute and chronic forms) from individuals
without this disease, but infected with other intestinal parasites (Ascaris lumbricoides, Trichuris
trichiura and hookworm). By contrast, SWAP IgG and SEA IgG were able to discriminate schistosomiasis
patients from healthy individuals and patients infected with other parasites (AUCs of 0.96 and 0.85,
respectively). Thus, it is possible to use a combination of serological tests, such as SEA IgA and SWAP IgG,
to simultaneously establish the diagnosis of schistosomiasis and discriminate the acute from the chronic
forms of the disease. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ. Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Aggeu Magalhães. Departamento de Imunologia. Laboratório de Bioquímica e Biologia Molecular. Recife, PE, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Aggeu Magalhães. Departamento de Imunologia. Laboratório de Bioquímica e Biologia Molecular. Recife, PE, Brasil. | pt_BR |
| Affilliation | Universidade Federal de Pernambuco. Recife, PE, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ. Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Aggeu Magalhães. Departamento de Imunologia. Laboratório de Bioquímica e Biologia Molecular. Recife, PE, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Aggeu Magalhães. Departamento de Imunologia. Laboratório de Bioquímica e Biologia Molecular. Recife, PE, Brasil. | pt_BR |
| Subject | Differential diagnosis | pt_BR |
| Subject | Schistosoma mansoni | pt_BR |
| Subject | Receiver operating characteristic | pt_BR |
| Subject | Acute schistosomiasis | pt_BR |
| Subject | Chronic schistosomiasis | pt_BR |
| e-ISSN | 1873-6254 | |
| Embargo date | 2022-01-01 | |
