Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/32521
Title: Discriminating acute from chronic human schistosomiasis mansoni
Authors: Beck, Lílian
Van-Lüme, Danielle S. M.
Souza, Joelma R.
Domingues, Ana L. C.
Favre, Tereza
Abath, Frederico G. C.
Montenegro, Silvia L. M.
Affilliation: Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ. Brasil.
Fundação Oswaldo Cruz. Centro de Pesquisas Aggeu Magalhães. Departamento de Imunologia. Laboratório de Bioquímica e Biologia Molecular. Recife, PE, Brasil.
Fundação Oswaldo Cruz. Centro de Pesquisas Aggeu Magalhães. Departamento de Imunologia. Laboratório de Bioquímica e Biologia Molecular. Recife, PE, Brasil.
Universidade Federal de Pernambuco. Recife, PE, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ. Brasil.
Fundação Oswaldo Cruz. Centro de Pesquisas Aggeu Magalhães. Departamento de Imunologia. Laboratório de Bioquímica e Biologia Molecular. Recife, PE, Brasil.
Fundação Oswaldo Cruz. Centro de Pesquisas Aggeu Magalhães. Departamento de Imunologia. Laboratório de Bioquímica e Biologia Molecular. Recife, PE, Brasil.
Abstract: Specific immunoglobulin (IgA, IgG and IgM) responses to different antigen targets (soluble eggs antigen – SEA, soluble worm adult protein – SWAP and keyhole limpet hole – KLH) were measured by enzyme linked immunosorbent assay (ELISA) in patients with acute and chronic schistosomiasis, aswell as patients without schistosomiasis. SEA IgA and KLH IgM presented high discriminatory powers to distinguish acute from chronic schistosomiasis, with calculated areas under the curve (AUCs) of 0.88 and 0.82, respectively, obtained from receiver operating characteristic (ROC) curve. On the other hand, these tests, particularly SEA IgA were not useful to distinguish schistosomiasis (including the acute and chronic forms) from individuals without this disease, but infected with other intestinal parasites (Ascaris lumbricoides, Trichuris trichiura and hookworm). By contrast, SWAP IgG and SEA IgG were able to discriminate schistosomiasis patients from healthy individuals and patients infected with other parasites (AUCs of 0.96 and 0.85, respectively). Thus, it is possible to use a combination of serological tests, such as SEA IgA and SWAP IgG, to simultaneously establish the diagnosis of schistosomiasis and discriminate the acute from the chronic forms of the disease.
Keywords: Differential diagnosis
Schistosoma mansoni
Receiver operating characteristic
Acute schistosomiasis
Chronic schistosomiasis
keywords: Diagnóstico Diferencial
Schistosoma mansoni
Características operacionais do receptor
Esquistossomose aguda
Esquistossomose crônica
Issue Date: 2008
Publisher: Elsevier
Citation: BECK, Lilian et al. Discriminating acute from chronic human schistosomiasis mansoni. Acta Tropica, v. 108, p. 229–233, 2008.
DOI: 10.1016/j.actatropica.2008.08.012
ISSN: 0001-706X
Copyright: restricted access
Appears in Collections:PE - IAM - Artigos de Periódicos
IOC - Artigos de Periódicos

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