Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/3256
Title: An Experimental and clinical assay with ketoconazole in the treatment of Chagas disease
Authors: Brener, Zigman
Cançado, Joaquim Romeu
Galvão, Lúcia Maria da Cunha
Luz, Zélia Maria Profeta da
Filardi, Leny de Souza
Pereira, Maria Elisabeth Soares
Santos, Luiz Mauro T.
Cançado, Catarina B.
Affilliation: Centro de Pesquisas René Rachou. Belo Horizonte, MG, Brasil
Universidade Federal de Minas Gerais. Faculdade de Medicina.Belo Horizonte, MG, Brasil
Centro de Pesquisas René Rachou. Belo Horizonte, MG, Brasil
Centro de Pesquisas René Rachou. Belo Horizonte, MG, Brasil
Centro de Pesquisas René Rachou. Belo Horizonte, MG, Brasil
Centro de Pesquisas René Rachou. Belo Horizonte, MG, Brasil
Centro de Pesquisas René Rachou. Belo Horizonte, MG, Brasil
Centro de Pesquisas René Rachou. Belo Horizonte, MG, Brasil
Abstract: Ketoconazole, an azole antifungic drug wich is already in the market has also been demonstrated to be active against Trypanosoma Cruzi experimental infections. In this paper we confirmed the drug effect and investigated its range of activity different T.cruzi strains naturally resistant or susceptible to both standard drugs Nifurtimox and Benznidazole plus Lovastatin (an inhibitor of sterol synthesis), wich has an antiproliferative effect against T. cruzi in vitro, failed to enhance the suppressive of Ketoconazole displayed when administered alone to infected mice. Finally, administration in chronic chagasic patients of Ketoconazole at doses used in the treatment of deep mycosis also failed to induce cure as demonstrated by parasitological and serological tests. The strategy of identify and test drugs wich are already in the market and fortuitously are active against T.cruzi has been discussed.
Keywords: Trypanosoma cruzi
Chagas disease
Ketoconazole
Issue Date: 1993
Publisher: Fundação Oswaldo Cruz
Citation: BRENER, Zigman et al. An Experimental and clinical assay with ketoconazole in the treatment of Chagas disease. Memórias do Instituto Oswaldo Cruz, v.88, n.1, p. 149-153, 1993.
Copyright: open access
Appears in Collections:MG - IRR - Artigos de Periódicos

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