Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/3269
Title: Genetic diversity of respiratory syncytial virus isolated during an epidemic period from children of northeastern Brazil.
Authors: Moura, Fernanda Edna Araújo
Blanc, Andrea
Frabasile, Sandra
Delfraro, Adriana
Sierra, Maria Jose de
Tome, Lorena
Ramos, Eduardo Antônio Gonçalves
Siqueira, Marilda Mendonça
Arbiza, Juan
Affilliation: Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil.
Universidad de la Republica. Facultad de Ciencias. Igua, Montevideo, Uruguay.
Universidad de la Republica, Facultad de Ciencias. Igua, Montevideo, Uruguay.
Universidad de la Republica, Facultad de Ciencias. Igua, Montevideo, Uruguay.
Universidad de la Republica, Facultad de Ciencias. Igua, Montevideo, Uruguay,
Universidad de la Republica, Facultad de Ciencias. Igua, Montevideo, Uruguay,
Fundação Oswaldo Cruz, Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil.
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil.
Universidad de la Republica. Facultad de Ciencias. Igua, Montevideo, Uruguay.
Abstract: Outbreaks of human respiratory syncytial virus (HRSV) are the leading cause of serious acute lower respiratory viral disease in many countries in different continents. Data on clinical and epidemiological aspects of HRSV infections in this country have been reported, but there is lack of data regarding the molecular epidemiology of this virus in Salvador. The genetic variability of HRSV isolated during an outbreak in Salvador, Brazil (1999) has been analysed. Partial sequences of the G protein gene of 13 isolates from antigenic group A and 4 isolates from antigenic group B of HRSV were determined. Nucleotide sequences of C-terminal G gene were compared to sequences of HRSV isolates from countries of South America and from the rest of the world available at the GenBank. Brazilian group A and B isolates were clustered into previously characterised genotypes: GA5, GA2, GA7, and GB3, SAB3, respectively. This is the first study of GA7 and SAB3 genotypes circulation in South American countries. It is interesting to point out that viruses isolated in Salvador appear to be closer related with those from Montevideo-Uruguay and Buenos Aires, Argentina strains, suggesting circulation of similar strains among different South American countries in different seasons. Moreover, viruses closely related genetically circulated in the same year in Salvador and distant places such as Mozambique, supporting the previous suggestion on the complexity of HRSV strain circulation patterns, and the high capability of HRSV spreading world-wide.
Keywords: RSV infections
Genetic Diversity
Salvador
Brazil
DeCS: Antígenos Virais
Variação Genética
Genes Virais
Genótipo
Epidemiologia Molecular
Filogenia
Dados de Sequência Molecular
Nasofaringe
Infecções por Vírus Respiratório Sincicial
Vírus Sinciciais Respiratórios
Análise de Sequência
Proteinas Virais
Lactente
Recem-Nascido
Pré-Escolar
Humanos
Issue Date: 2004
Citation: MOURA, F.E. et al. Genetic diversity of respiratory syncytial virus isolated during an epidemic period from children of northeastern Brazil. Journal of Medical Virology, v. 74, n. 1, p. 156-160, sep. 2004.
DOI: DOI 10.1002/jmv.20159
ISSN: 0146-6615
Copyright: open access
Appears in Collections:IGM - Artigos de Periódicos

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