| Author | Oliveira, Marta | |
| Author | Rodrigues, Maria João | |
| Author | Pereira, Catarina Alexandra Guerreiro | |
| Author | Monte Neto, Rubens Lima do | |
| Author | Santos Junior, Policarpo Ademar | |
| Author | Neng, Nuno da Rosa | |
| Author | Nogueira, José Manuel Florencio | |
| Author | Varela, João | |
| Author | Barreira, Luisa | |
| Author | Custodio, Luisa | |
| Access date | 2019-04-24T16:29:25Z | |
| Available date | 2019-04-24T16:29:25Z | |
| Document date | 2018 | |
| Citation | OLIVEIRA, Marta et al. First report of the in vitro antileishmanial properties of extremophile plants from the Algarve Coast. Natural Product Research, v. 32, n. 5, p. 600-604, 2018. | pt_BR |
| ISSN | 1478-6419 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/32720 | |
| Language | eng | pt_BR |
| Publisher | Taylor & Francis | pt_BR |
| Rights | restricted access | pt_BR |
| Subject in Portuguese | antiparasitas | pt_BR |
| Subject in Portuguese | Leishmania infantum | pt_BR |
| Subject in Portuguese | doenças tropicais neglicenciadas | pt_BR |
| Subject in Portuguese | leishmaiose visceral | pt_BR |
| Title | First report of the in vitro antileishmanial properties of extremophile plants from the Algarve Coast | pt_BR |
| Type | Article | |
| DOI | 10.1080/14786419.2017.1326489 | |
| Abstract | This work reports for the first time the in vitro anti Leishmania infantum activity of acetone and dichloromethane (DCM) extracts from 25 extremophile plants from Southern Portugal. DCM extracts from Inula chritmoides and Spergularia rubra were active against axenic promastigotes and intracellular amastigotes, had anti-inflammatory properties on lipopolysaccharide (LPS)-stimulated macrophages, inhibited acetylcholinesterase and had no haemolytic activity on human erythrocytes. Eleven phenolics were identified by highperformance liquid chromatography with diode-array detection (HPLC-DAD) in I. crithmoides and one phenolic in S. rubra. Isolation and identification of the active molecules is in progress. | pt_BR |
| Affilliation | Faculty of Sciences and Technology. Centre of Marine Sciences. University of Algarve. Faro, Portugal. | pt_BR |
| Affilliation | Faculty of Sciences and Technology. Centre of Marine Sciences. University of Algarve. Faro, Portugal. | pt_BR |
| Affilliation | Faculty of Sciences and Technology. Centre of Marine Sciences. University of Algarve. Faro, Portugal. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, MG, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, MG, Brasil. | pt_BR |
| Affilliation | Universidade de Lisboa. Faculdade de Ciências. Departamento de Química e Bioquímica. Lisboa, Portugal. | pt_BR |
| Affilliation | Universidade de Lisboa. Faculdade de Ciências. Departamento de Química e Bioquímica. Lisboa, Portugal. | pt_BR |
| Affilliation | Faculty of Sciences and Technology. Centre of Marine Sciences. University of Algarve. Faro, Portugal. | pt_BR |
| Affilliation | Faculty of Sciences and Technology. Centre of Marine Sciences. University of Algarve. Faro, Portugal. | pt_BR |
| Affilliation | Faculty of Sciences and Technology. Centre of Marine Sciences. University of Algarve. Faro, Portugal. | pt_BR |
| Subject | Antiparasitic | pt_BR |
| Subject | halophytes | pt_BR |
| Subject | Inula chritmoides | pt_BR |
| Subject | Leishmania infantum | pt_BR |
| Subject | neglected tropical diseases | pt_BR |
| Subject | Spergularia rubra | pt_BR |
| Subject | visceral leishmaniasis | pt_BR |
| Embargo date | 2150-01-01 | |
| xmlui.metadata.dc.subject.ods | 03 Saúde e Bem-Estar | |
