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2150-01-01
Sustainable Development Goals
03 Saúde e Bem-Estar
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FIRST REPORT OF THE IN VITRO ANTILEISHMANIAL PROPERTIES OF EXTREMOPHILE PLANTS FROM THE ALGARVE COAST
Oliveira, Marta et al. | Date Issued: 2018
Author
Oliveira, Marta
Rodrigues, Maria João
Pereira, Catarina Alexandra Guerreiro
Monte Neto, Rubens Lima do
Santos Junior, Policarpo Ademar
Neng, Nuno da Rosa
Nogueira, José Manuel Florencio
Varela, João
Barreira, Luisa
Custodio, Luisa
Affilliation
Faculty of Sciences and Technology. Centre of Marine Sciences. University of Algarve. Faro, Portugal.
Faculty of Sciences and Technology. Centre of Marine Sciences. University of Algarve. Faro, Portugal.
Faculty of Sciences and Technology. Centre of Marine Sciences. University of Algarve. Faro, Portugal.
Fundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, MG, Brasil.
Fundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, MG, Brasil.
Universidade de Lisboa. Faculdade de Ciências. Departamento de Química e Bioquímica. Lisboa, Portugal.
Universidade de Lisboa. Faculdade de Ciências. Departamento de Química e Bioquímica. Lisboa, Portugal.
Faculty of Sciences and Technology. Centre of Marine Sciences. University of Algarve. Faro, Portugal.
Faculty of Sciences and Technology. Centre of Marine Sciences. University of Algarve. Faro, Portugal.
Faculty of Sciences and Technology. Centre of Marine Sciences. University of Algarve. Faro, Portugal.
Abstract
This work reports for the first time the in vitro anti Leishmania infantum activity of acetone and dichloromethane (DCM) extracts from 25 extremophile plants from Southern Portugal. DCM extracts from Inula chritmoides and Spergularia rubra were active against axenic promastigotes and intracellular amastigotes, had anti-inflammatory properties on lipopolysaccharide (LPS)-stimulated macrophages, inhibited acetylcholinesterase and had no haemolytic activity on human erythrocytes. Eleven phenolics were identified by highperformance liquid chromatography with diode-array detection (HPLC-DAD) in I. crithmoides and one phenolic in S. rubra. Isolation and identification of the active molecules is in progress.
Keywords in Portuguese
antiparasitas
Leishmania infantum
doenças tropicais neglicenciadas
leishmaiose visceral
 
Keywords
Antiparasitic
halophytes
Inula chritmoides
Leishmania infantum
neglected tropical diseases
Spergularia rubra
visceral leishmaniasis
 
Publisher
Taylor & Francis
Citation
OLIVEIRA, Marta et al. First report of the in vitro antileishmanial properties of extremophile plants from the Algarve Coast. Natural Product Research, v. 32, n. 5, p. 600-604, 2018.
DOI
10.1080/14786419.2017.1326489
ISSN
1478-6419