Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/32836
Title: Sex-specific patterns in the association between salt intake and blood pressure: The ELSA-Brasil study
Authors: Mill, José Geraldo
Baldo, Marcelo P.
Molina, Maria Del Carmen B.
Schmidt, Maria Inês
Barreto, Sandhi M.
Chor, Dora
Griep, Rosane H.
Matos, Sheila M.
Ribeiro, Antonio Luiz P.
Duncan, Bruce B.
Aquino, Estela M.
Lotufo, Paulo A.
Bensenor, Isabela
Affilliation: Universidade Federal do Espírito Santo. Departamento de Ciências Fisiológicas. Vitória, ES, Brasil.
Universidade Estadual de Montes Claros. Departamento de Patofisiologia. Montes Claros, MG, Brasil / Faculdades Integradas Pitágoras. Departamento de Medicina. Montes Claros, MG, Brasil.
Universidade Federal do Espírito Santo. Departamento de Nutrição. Vitória, ES, Brasil.
Universidade Federal do Rio Grande do Sul. Faculdade de Medicina. Hospital das Clínicas. Porto Alegre, RS, Brasil.
Universidade Federal de Minas Gerais. Faculdade de Medicina. Hospital das Clínicas. Belo Horizonte, MG, Brasil.
Fundação Oswaldo Cruz. Escola Nacional de Saúde Pública Sergio Arouca. Rio de Janeiro, RJ. Brasil.
Fundação Oswaldo Cruz. Escola Nacional de Saúde Pública Sergio Arouca. Rio de Janeiro, RJ. Brasil.
Universidade Federal da Bahia. Instituto de Saúde Coletiva. Salvador, BA, Brasil.
Universidade Federal de Minas Gerais. Faculdade de Medicina. Hospital das Clínicas. Belo Horizonte, MG, Brasil.
Universidade Federal do Rio Grande do Sul. Faculdade de Medicina. Hospital das Clínicas. Porto Alegre, RS, Brasil.
Universidade Federal da Bahia. Instituto de Saúde Coletiva. Salvador, BA, Brasil.
Universidade de São Paulo. Faculdade de Medicina. Hospital Universitário. São Paulo, SP, Brasil.
Universidade de São Paulo. Faculdade de Medicina. Hospital Universitário. São Paulo, SP, Brasil.
Abstract: Blood pressure (BP) is a strong cardiovascular risk factor, predicting cardiovascular mortality in the general population. High salt consumption is a major contributor of increased BP and hypertension. However, there is a controversy on whether BP response to salt intake would be sex-specific. Thus, we aimed to verify the changes in BP according to different salt intake in men and women in a large sample of adults. The present analysis refers to 12 813 participants (from 35 to 64 years) with a validated 12-hour overnight urine collection in which salt intake was estimated. A set of questionnaires, clinical examination, and laboratory tests were carried out during a single visit to one of the six investigation centers involved. Salt intake was 12.9 ± 5.9 g/d in men and 9.3 ± 4.3 g/d in women. BP increases as salt intake increases, regardless of using BP-lowering medication. The slope of increase in BP elicited by salt intake was significantly higher in women than in men. Thus, the increase in BP by salt intake was stepper in women even after controlling for confounders, regardless of using BP-lowering medication or being hypertensive. In conclusion, salt intake is elevated in this large sample of Brazilian adults in which only a few participants are compliant with the recommendation. Also, women have a higher responsiveness of BP according to salt intake than men, and it is not associated with age, BP level, or the use of BP-lowering medication.
Keywords: Blood pressure
ELSA‐Brasil study
Sex‐specific patterns
Salt intake
keywords: Padrões específicos de sexo
Ingestão de sal
Pressão arterial
Estudo ELSA-Brasil
Issue Date: 2019
Publisher: Wiley 12 Months
Citation: MILL, José Geraldo et al. Sex‐specific patterns in the association between salt intake and blood pressure: The ELSA‐Brasil study. J. Clin. Hypertens., v. 21, p. 502-509, 2019.
DOI: 10.1111/jch.13509
ISSN: 1524-6175
Copyright: restricted access
Appears in Collections:ENSP - Artigos de Periódicos

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