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DIFFERENTIAL SHEDDING AND ANTIBODY KINETICS OF ZIKA AND CHIKUNGUNYA VIRUSES, BRAZIL
Bozza, Fernando A. et al. | Date Issued: 2019
Author
Bozza, Fernando A.
Moreira-Soto, Andres
Rockstroh, Alexandra
Fischer, Carlo
Nascimento, Alessandra Dantas do
Calheiros, Andrea S.
Drosten, Christian
Bozza, Patrícia T.
Souza, Thiago Moreno L.
Ulbert, Sebastian
Drexler, Jan Felix
Affilliation
Fundação Oswaldo Cruz. Instituto Nacional de Doenças Infecciosas Evandro Chagas. Rio de Janeiro, RJ. Brasil.
Berlin Institute of Health. Institute of Virology. Berlin, Germany.
Fraunhofer Institute for Cell Therapy and Immunology. Leipzig, Germany.
Berlin Institute of Health. Institute of Virology. Berlin, Germany.
Fundação Oswaldo Cruz. Instituto Nacional de Doenças Infecciosas Evandro Chagas. Rio de Janeiro, RJ. Brasil / Instituto D`Or de Pesquisa e Educação. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ. Brasil.
German Centre for Infection Research. Berlin, Germany.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ. Brasil.
Fundação Oswaldo Cruz. Centro de Desenvolvimento Tecnológico em Saúde. Rio de Janeiro, RJ, Brasil.
Fraunhofer Institute for Cell Therapy and Immunology. Leipzig, Germany.
Martsinovsky Institute of Medical Parasitology. Tropical and Vector-Borne Diseases. Sechenov University. Moscow, Russia.
Abstract
In seroconversion panels obtained from patients from Brazil, diagnostic testing for Zika virus infection was improved by combining multiple antibody isotypes, techniques, and antigens, but sensitivity remained suboptimal. In contrast, chikungunya virus diagnostic testing was unambiguous. Recurrent recent arbovirus infections suggested by serologic data and unspecific symptoms highlight the need for exhaustive virologic testing.
Keywords in Portuguese
Zika virus
Chikungunya
Cinética de Anticorpos
Brasil
Derramamento Diferencial
 
Keywords
Zika virus
Chikungunya
Differential Shedding
Antibody Kinetics
Brazil
 
Publisher
Centers for Disease Control and Prevention
Citation
BOZZA, Fernando A. et al. Differential Shedding and Antibody Kinetics of Zika and Chikungunya Viruses, Brazil. Emerging Infectious Diseases, v. 25, n. 2, p.311-315, Feb. 2019.
DOI
10.3201/eid2502.180166
ISSN
1080-6040