| Author | Del-Rei, Rodrigo Pimenta | |
| Author | Leony, Leonardo Maia | |
| Author | Celedon, Paola Alejandra Fiorani | |
| Author | Zanchin, Nilson Ivo Tonin | |
| Author | Reis, Mitermayer Galvão dos | |
| Author | Gomes, Yara de Miranda | |
| Author | Schijman, Alejandro Gabriel | |
| Author | Longhi, Silvia Andrea | |
| Author | Santos, Fred Luciano Neves | |
| Access date | 2019-05-07T16:39:03Z | |
| Available date | 2019-05-07T16:39:03Z | |
| Document date | 2019 | |
| Citation | DEL-REI, Rodrigo Pimenta et al. Detection of anti-Trypanosoma cruzi antibodies by chimeric antigens in chronic Chagas disease-individuals from endemic South American countries. Plos One, v. 14, n. 4, p. 1-12, 2019. | pt_BR |
| ISSN | 1932-6203 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/32985 | |
| Sponsorship | Fundación
Bunge y Born 2012 Dr. Silvia Andrea Longhi;
Consejo Nacional de Investigaciones Científicas y
Tecnológicas PIP/0974-2011 Dr. Alejandro Gabriel
Schijman; Gonçalo Moniz Institute PROEP/IGM
400904/2013-6 Dr. Mitermayer Galvão dos Reis;Coordination of Superior Level Staff Improvement
CAPES - PROEX 0720/2018 Dr. Fred Luciano
Neves Santos; National Council for Scientific and
Technological Development CNPq Proc. No.
312195/2015-0 Dr. Nilson Ivo Tonin Zanchin; and
National Council for Scientific and Technological
Development CNPq Proc. No. 307319/2016-4 Dr.
Mitermayer Galvão dos Reis. The funders were not
involved in the design of the study, in the
collection, analysis and interpretation of the data,
or in writing the manuscript. | pt_BR |
| Language | eng | pt_BR |
| Publisher | Public Library of Science | pt_BR |
| Rights | open access | pt_BR |
| Subject in Portuguese | Trypanosoma cruzi | pt_BR |
| Subject in Portuguese | Doença de Chagas | pt_BR |
| Subject in Portuguese | Antígenos | pt_BR |
| Subject in Portuguese | Proteínas Quiméricas | pt_BR |
| Subject in Portuguese | Diagnóstico | pt_BR |
| Subject in Portuguese | Brasil | pt_BR |
| Title | Detection of anti-Trypanosoma cruzi antibodies by chimeric antigens in chronic Chagas disease-individuals from endemic South American countries | pt_BR |
| Type | Article | pt_BR |
| DOI | 10.1371/journal.pone.0215623 | |
| Abstract | Laboratory diagnosis of chronic Chagas disease is a troubling factor due to lack of reference tests. The WHO suggests the use of two distinct commercial serological tests in parallel. The performance of commercial immunoassays might fluctuate depending on the antigenic matrices and the local strains of T. cruzi in different geographical settings. The use of antigenic matrices based on chimeric proteins can solve these limitations. Here, we evaluated the diagnostic performance of two chimeric T. cruzi antigens (IBMP-8.1 and -8.4) to diagnose chronic Chagas disease in individuals from endemic South American countries. | pt_BR |
| Affilliation | Faculty of Technology and Sciences of Bahia. Salvador, BA, Brazil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil. | pt_BR |
| Affilliation | Molecular Biology Institute of Paraná. Curitiba, PR, Brazil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Carlos Chagas. Curitiba, PR, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Federal University of Bahia. Department of Pathology and Legal Medicine. Salvador, BA, Brazil / Yale University. School of Public Health. Department of Epidemiology of Microbial Diseases. New Haven, Connecticut, United States of America. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Recife, PE, Brasil. | pt_BR |
| Affilliation | Institute for Research on Genetic Engineering and Molecular Biology “Dr Héctor Torres”. Laboratory of Molecular Biology of Chagas Disease. Buenos Aires, Argentina. | pt_BR |
| Affilliation | Institute for Research on Genetic Engineering and Molecular Biology “Dr Héctor Torres”. Laboratory of Molecular Biology of Chagas Disease. Buenos Aires, Argentina. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil. | pt_BR |
| Subject | Trypanosoma cruzi | pt_BR |
| Subject | Chagas disease | pt_BR |
| Subject | Antigens | pt_BR |
| Subject | Chimeric proteins | pt_BR |
| Subject | Diagnostics | pt_BR |
| Subject | Brazil | pt_BR |
| xmlui.metadata.dc.subject.ods | 03 Saúde e Bem-Estar | |
