Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/32985
Title: Detection of anti-Trypanosoma cruzi antibodies by chimeric antigens in chronic Chagas disease-individuals from endemic South American countries
Authors: Del-Rei, Rodrigo Pimenta
Leony, Leonardo Maia
Celedon, Paola Alejandra Fiorani
Zanchin, Nilson Ivo Tonin
Reis, Mitermayer Galvão dos
Gomes, Yara de Miranda
Schijman, Alejandro Gabriel
Longhi, Silvia Andrea
Santos, Fred Luciano Neves
Affilliation: Faculty of Technology and Sciences of Bahia. Salvador, BA, Brazil.
Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil.
Molecular Biology Institute of Paraná. Curitiba, PR, Brazil.
Fundação Oswaldo Cruz. Instituto Carlos Chagas. Curitiba, PR, Brasil.
Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Federal University of Bahia. Department of Pathology and Legal Medicine. Salvador, BA, Brazil / Yale University. School of Public Health. Department of Epidemiology of Microbial Diseases. New Haven, Connecticut, United States of America.
Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Recife, PE, Brasil.
Institute for Research on Genetic Engineering and Molecular Biology “Dr Héctor Torres”. Laboratory of Molecular Biology of Chagas Disease. Buenos Aires, Argentina.
Institute for Research on Genetic Engineering and Molecular Biology “Dr Héctor Torres”. Laboratory of Molecular Biology of Chagas Disease. Buenos Aires, Argentina.
Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil.
Abstract: Laboratory diagnosis of chronic Chagas disease is a troubling factor due to lack of reference tests. The WHO suggests the use of two distinct commercial serological tests in parallel. The performance of commercial immunoassays might fluctuate depending on the antigenic matrices and the local strains of T. cruzi in different geographical settings. The use of antigenic matrices based on chimeric proteins can solve these limitations. Here, we evaluated the diagnostic performance of two chimeric T. cruzi antigens (IBMP-8.1 and -8.4) to diagnose chronic Chagas disease in individuals from endemic South American countries.
Keywords: Trypanosoma cruzi
Chagas disease
Antigens
Chimeric proteins
Diagnostics
Brazil
keywords: Trypanosoma cruzi
Doença de Chagas
Antígenos
Proteínas Quiméricas
Diagnóstico
Brasil
Issue Date: 2019
Publisher: Public Library of Science
Citation: DEL-REI, Rodrigo Pimenta et al. Detection of anti-Trypanosoma cruzi antibodies by chimeric antigens in chronic Chagas disease-individuals from endemic South American countries. Plos One, v. 14, n. 4, p. 1-12, 2019.
DOI: 10.1371/journal.pone.0215623
ISSN: 1932-6203
Copyright: open access
Appears in Collections:PR - ICC - Artigos de Periódicos
BA - IGM - Artigos de Periódicos

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