| Author | Silva, José V. J. | |
| Author | Lopes, Thaísa R. R. | |
| Author | Oliveira-Filho, Edmilson F. de | |
| Author | Oliveira, Renato A. S. | |
| Author | Durães-Carvalho, Ricardo | |
| Author | Gil, Laura H. V. G. | |
| Access date | 2019-05-10T12:41:27Z | |
| Available date | 2019-05-10T12:41:27Z | |
| Document date | 2018 | |
| Citation | SILVA, José V. J. et al. Current status, challenges and perspectives in the development of vaccines against yellow fever, dengue, Zika and chikungunya viruses. Acta Tropica, v. 182, p. 257–263, Jun. 2018. | pt_BR |
| ISSN | 1873-6254 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/33031 | |
| Sponsorship | E.F. Oliveira-Filho e R. Durães-Carvalho são apoiados pelas bolsas DCF do FACEPE e do DCR do MCT / CNPq. J.V.J. Silva Júnior é apoiado pela Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES). T.R.R. A Lopes é apoiada pelo Conselho Nacional de Desvolvimento Científico e Tecnológico (CNPq). | pt_BR |
| Language | eng | pt_BR |
| Rights | restricted access | pt_BR |
| Title | Current status, challenges and perspectives in the development of vaccines against yellow fever, dengue, Zika and chikungunya viruses | pt_BR |
| Type | Article | pt_BR |
| DOI | 10.1016/j.actatropica.2018.03.009 | |
| Abstract | Emerging and re-emerging viral infections transmitted by insect vectors (arthopode-borne viruses, arbovirus) are a serious threat to global public health. Among them, yellow fever (YFV), dengue (DENV), chikungunya (CHIKV) and Zika (ZIKV) viruses are particularly important in tropical and subtropical regions. Although vector control is one of the most used prophylactic measures against arboviruses, it often faces obstacles, such as vector diversity, uncontrolled urbanization and increasing resistance to insecticides. In this context, vaccines may be the best control strategy for arboviral diseases. Here, we provide a general overview about licensed vaccines and the most advanced vaccine candidates against YFV, DENV, CHIKV and ZIKV. In particular, we highlight vaccine difficulties, the current status of the most advanced strategies and discuss how the molecular characteristics of each virus can influence the choice of the different vaccine formulations. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Departamento de Virologia e Terapia Experimental. Recife, PE, Brasil. | pt_BR |
| Affilliation | Federal University of Pernambuco. Virology Sector. Laboratory of Immunopathology Keizo Asami. Recife, PE, Brazil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Departamento de Virologia e Terapia Experimental. Recife, PE, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Departamento de Virologia e Terapia Experimental. Recife, PE, Brasil / Federal University of Pernambuco. Departament of Pharmaceutical Sciences. Recife, PE, Brazil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Departamento de Virologia e Terapia Experimental. Recife, PE, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Departamento de Virologia e Terapia Experimental. Recife, PE, Brasil. | pt_BR |
| Subject | Arboviruses | pt_BR |
| Subject | Disease control | pt_BR |
| Subject | Vaccination | pt_BR |
| Subject | Public health | pt_BR |
| DeCS | Animais | pt_BR |
| DeCS | Arbovírus / imunologia | pt_BR |
| DeCS | Febre Chikungunya / prevenção & controle | pt_BR |
| DeCS | Chikungunya Fever / transmissão | pt_BR |
| DeCS | Vírus Chikungunya / imunologia | pt_BR |
| DeCS | Dengue / prevenção & controle | pt_BR |
| DeCS | Dengue / transmissão | pt_BR |
| DeCS | Vacinas contra Dengue / imunologia | pt_BR |
| DeCS | Vírus da Dengue / imunologia | pt_BR |
| DeCS | Descoberta de drogas | pt_BR |
| DeCS | Humanos | pt_BR |
| DeCS | Vetores de insetos / imunologia | pt_BR |
| DeCS | Vacinas virais / imunologia | pt_BR |
| DeCS | Febre Amarela / prevenção & controle | pt_BR |
| DeCS | Febre Amarela / transmissão | pt_BR |
| DeCS | Vacina contra Febre Amarela / imunologia | pt_BR |
| DeCS | Zika Virus / imunologia | pt_BR |
| DeCS | Infecção por vírus Zika / prevenção & controle | pt_BR |
| DeCS | Infecção / transmissão do vírus Zika | pt_BR |
| Embargo date | 2050-01-01 | |
| xmlui.metadata.dc.subject.ods | 03 Saúde e Bem-Estar | |
