Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/33031
Title: Current status, challenges and perspectives in the development of vaccines against yellow fever, dengue, Zika and chikungunya viruses
Authors: Silva, José V. J.
Lopes, Thaísa R. R.
Oliveira-Filho, Edmilson F. de
Oliveira, Renato A. S.
Durães-Carvalho, Ricardo
Gil, Laura H. V. G.
Affilliation: Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Departamento de Virologia e Terapia Experimental. Recife, PE, Brasil.
Federal University of Pernambuco. Virology Sector. Laboratory of Immunopathology Keizo Asami. Recife, PE, Brazil.
Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Departamento de Virologia e Terapia Experimental. Recife, PE, Brasil.
Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Departamento de Virologia e Terapia Experimental. Recife, PE, Brasil / Federal University of Pernambuco. Departament of Pharmaceutical Sciences. Recife, PE, Brazil.
Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Departamento de Virologia e Terapia Experimental. Recife, PE, Brasil.
Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Departamento de Virologia e Terapia Experimental. Recife, PE, Brasil.
Abstract: Emerging and re-emerging viral infections transmitted by insect vectors (arthopode-borne viruses, arbovirus) are a serious threat to global public health. Among them, yellow fever (YFV), dengue (DENV), chikungunya (CHIKV) and Zika (ZIKV) viruses are particularly important in tropical and subtropical regions. Although vector control is one of the most used prophylactic measures against arboviruses, it often faces obstacles, such as vector diversity, uncontrolled urbanization and increasing resistance to insecticides. In this context, vaccines may be the best control strategy for arboviral diseases. Here, we provide a general overview about licensed vaccines and the most advanced vaccine candidates against YFV, DENV, CHIKV and ZIKV. In particular, we highlight vaccine difficulties, the current status of the most advanced strategies and discuss how the molecular characteristics of each virus can influence the choice of the different vaccine formulations.
Keywords: Arboviruses
Disease control
Vaccination
Public health
DeCS: Animais
Arbovírus / imunologia
Febre Chikungunya / prevenção & controle
Chikungunya Fever / transmissão
Vírus Chikungunya / imunologia
Dengue / prevenção & controle
Dengue / transmissão
Vacinas contra Dengue / imunologia
Vírus da Dengue / imunologia
Descoberta de drogas
Humanos
Vetores de insetos / imunologia
Vacinas virais / imunologia
Febre Amarela / prevenção & controle
Febre Amarela / transmissão
Vacina contra Febre Amarela / imunologia
Zika Virus / imunologia
Infecção por vírus Zika / prevenção & controle
Infecção / transmissão do vírus Zika
Issue Date: 2018
Citation: SILVA, José V. J. et al. Current status, challenges and perspectives in the development of vaccines against yellow fever, dengue, Zika and chikungunya viruses. Acta Tropica, v. 182, p. 257–263, Jun. 2018.
DOI: 10.1016/j.actatropica.2018.03.009
ISSN: 1873-6254
Copyright: restricted access
Appears in Collections:PE - IAM - Artigos de Periódicos

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