Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/33042
Title: Progressive Chagas' cardiomyopathy is associated with low selenium levels
Authors: Rivera, M. T.
Souza, A. P.
Moreno, A. H. M.
Xavier, S. S.
Gomes, J. A. S.
Rocha, M. O. C.
Oliveira, R. C
Neve, J.
Vanderpas, J.
Jorge, T. C. A.
Affilliation: Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Ultra-estrutura e Biologia Celular. Laboratório de Biologia Celular. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Ultra-estrutura e Biologia Celular. Laboratório de Biologia Celular. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Centro de Pesquisas Hospital Evandro Chagas. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Centro de Pesquisas Hospital Evandro Chagas. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Laboratório de Imunologia Celular e Molecular. Belo Horizonte, MG, Brasil.
Universidade Federal de Minas Gerais. Faculdade de Medicina. Belo Horizonte, MG, Brasil.
Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Laboratório de Imunologia Celular e Molecular. Belo Horizonte, MG, Brasil.
Université Libre de Bruxelles. Institut de Pharmacie. Brussels, Belgium.
Hopital Ambroise-Paré. Brussels, Belgium.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Ultra-estrutura e Biologia Celular. Laboratório de Biologia Celular. Rio de Janeiro, RJ, Brasil.
Abstract: Selenium (Se) deficiency is linked with some cardiomyopathies. Its status was determined in 170 patients with chronic Chagas’ disease from 2 Brazilian regions (Rio de Janeiro and Belo Horizonte), clinically stratified into groups as follows: indeterminate or asymptomatic (IND); cardiac asymptomatic (CARDa); cardiac symptomatic with moderate to severe heart dysfunction (CARDb); and healthy adults (HA), used for comparison. In most HA, Se levels were normal, excluding an overall Se deficiency. Se was significantly lower in CARDb than in HA, IND, or CARDa patients. This was not associated with a concomitant decrease in activity of glutathione peroxidase. Thyrotropin was normal, excluding iodine deficiency. Se correlated positive and significantly with ventricular ejection fraction (assessed via echocardiography). Asymptomatic children with acute Chagas’ disease had normalSe as wellas 5 noninfectious cases of cardiomyopathy. Low Se was found in 6 of 10 chagasic patients with digestive megasyndromes. Thus, the decrease in Se in chagasic patients seems to be a biological marker for Trypanosoma cruzi infection and related to the progression of pathology.
Keywords: Chagas’ disease
Cardiomyopathy
Selenium
Issue Date: 2002
Publisher: American Society of Tropical Medicine and Hygiene
Citation: RIVERA, Maria Teresa et al. Progressive Chagas' cardiomyopathy is associated with low selenium levels. American Journal of Tropical Medicine and Hygiene, v. 66, n. 6, p. 706-712, 2002.
DOI: 10.4269/ajtmh.2002.66.706
ISSN: 0002-9637
Copyright: restricted access
Appears in Collections:IOC - Artigos de Periódicos
MG - IRR - Artigos de Periódicos
INI - Artigos de Periódicos

Files in This Item:
File Description SizeFormat 
ve_Rivera_Maria_etal_INI_2002.pdf187.17 kBAdobe PDF    Request a copy



FacebookTwitterDeliciousLinkedInGoogle BookmarksBibTex Format mendeley Endnote DiggMySpace

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.