| Author | Romanos, M. T. | |
| Author | Serpa, M. J. A. | |
| Author | Mourão, P. A. | |
| Author | Valentin, Y. Y. | |
| Author | Costa, S. S. | |
| Author | Pereira, M. S. | |
| Author | Miranda, M. M. | |
| Author | Gonçalves, J. L. | |
| Author | Wigg, M. D. | |
| Access date | 2019-05-17T14:11:52Z | |
| Available date | 2019-05-17T14:11:52Z | |
| Document date | 2002 | |
| Citation | ROMANOS, M. T. V. et al. A sulphated fucan from the Laminaria abyssalis inhibits the human T cell lymphotropic virus type 1-induced syncytium formation in HeLa cells. Antiviral Chemistry and Chemotherapy, v. 13, n. 4, p. 219-221, 2002. | pt_BR |
| ISSN | 0956-3202 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/33130 | |
| Description | Maria José de Andrada Serpa. Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta a informação no documento. | pt_BR |
| Language | eng | pt_BR |
| Publisher | SAGE Publications | pt_BR |
| Rights | open access | pt_BR |
| Title | A sulphated fucan from the Laminaria abyssalis inhibits the human T cell lymphotropic virus type 1-induced syncytium formation in HeLa cells | pt_BR |
| Type | Article | pt_BR |
| DOI | 10.1177/095632020201300402 | |
| Abstract | This work evaluated the effect of a sulphated fucan extracted from the Laminaria abyssalis marine algae on the human T cell lymphotropic virus type 1 (HTLV-1)-induced syncytium formation. The experiments were carried out in HeLa cells cocultured with a HTLV-1-infected T cell line (C91/PL cells) in the presence of the sulphated
polysaccharide at concentration below that corresponding to the ED50. The sulphated fucan inhibited almost 100% of the syncytium formation at concentration of 100 µg/ml and was still active (>95%) at a concentration of 25 µg/ml. It was also observed that the best inhibition occurred when the compound was added in the first 2 h of the cell-to-cell contact. This is the first report showing that a purified sulphated polysaccharide, extracted from marine algae, is able to inhibit the cell-tocell contact essential for the spreading of the HTLV-1. | pt_BR |
| Affilliation | Universidade Federal do Rio de Janeiro. Instituto de Microbiologia Prof. Paulo de Góes. Departamento de Virologia. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Instituto Nacional do Câncer. Setor de Pesquisa Básica. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Universidade Federal do Rio de Janeiro. Hospital Universitário Clementino Fraga Filho. Rio de Janeiro, RJ, Brasil / Universidade Federal do Rio de Janeiro. Departamento de Bioquímica Médica. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Universidade Federal do Rio de Janeiro. Departamento de Botânica do Instituto de Biologia. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Universidade Federal do Rio de Janeiro. Núcleo de Pesquisa de Produtos Naturais. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Universidade Federal do Rio de Janeiro. Hospital Universitário Clementino Fraga Filho. Rio de Janeiro, RJ, Brasil / Universidade Federal do Rio de Janeiro. Departamento de Bioquímica Médica. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Universidade Federal do Rio de Janeiro. Instituto de Microbiologia Prof. Paulo de Góes. Departamento de Virologia. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Universidade Federal do Rio de Janeiro. Instituto de Microbiologia Prof. Paulo de Góes. Departamento de Virologia. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Universidade Federal do Rio de Janeiro. Instituto de Microbiologia Prof. Paulo de Góes. Departamento de Virologia. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Subject | HTLV-1 | pt_BR |
| Subject | Laminaria abyssalis | pt_BR |
| Subject | Marine algae | pt_BR |
| Subject | Sulphated fucan | pt_BR |
| Subject | Syncytium inhibition | pt_BR |
| e-ISSN | 0956-3202 | |
| Embargo date | 2020-05-17 | |
| xmlui.metadata.dc.subject.ods | 14 Vida na água | |
