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2020-05-17
Sustainable Development Goals
14 Vida na águaCollections
- INI - Artigos de Periódicos [3646]
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A SULPHATED FUCAN FROM THE LAMINARIA ABYSSALIS INHIBITS THE HUMAN T CELL LYMPHOTROPIC VIRUS TYPE 1-INDUCED SYNCYTIUM FORMATION IN HELA CELLS
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This work evaluated the effect of a sulphated fucan extracted from the Laminaria abyssalis marine algae on the human T cell lymphotropic virus type 1 (HTLV-1)-induced syncytium formation. The experiments were carried out in HeLa cells cocultured with a HTLV-1-infected T cell line (C91/PL cells) in the presence of the sulphated
polysaccharide at concentration below that corresponding to the ED50. The sulphated fucan inhibited almost 100% of the syncytium formation at concentration of 100 µg/ml and was still active (>95%) at a concentration of 25 µg/ml. It was also observed that the best inhibition occurred when the compound was added in the first 2 h of the cell-to-cell contact. This is the first report showing that a purified sulphated polysaccharide, extracted from marine algae, is able to inhibit the cell-tocell contact essential for the spreading of the HTLV-1.
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